The Instruction of 2,7-Dibromo-N-phenylcarbazole

Instructions for the synthesis of 2,7-Dibromo-N-phenylcarbazole:

1. Prepare a solution of N-phenylcarbazide in a suitable solvent, such as DMF or acetonitrile.
   The concentration of the solution should be approximately 1-5 M.
   
2. Add a solution of NaBr in water to the solution of N-phenylcarbazide, stirring constantly.
   The concentration of the NaBr solution should be approximately 5-10 M.
   
3. Continue stirring the mixture for several hours, until the reaction is complete.
   This can be determined by TLC or HPLC analysis.
   
4. Pour the reaction mixture into a separatory funnel and add a small amount of water.
   Shake the mixture vigorously, then allow it to settle.
   Draw off the lower layer and rinse the residue with a small amount of water.
   
5. Transfer the organic layer to a dry, round-bottomed flask equipped with a magnetic stirrer and a condenser.
   
6. Add a solution of K2CO3 in water to the organic layer, stirring constantly.
   The concentration of the K2CO3 solution should be approximately 5-10 M.
   
7. Continue stirring the mixture for several hours, until the reaction is complete.
   This can be determined by TLC or HPLC analysis.
   
8. Pour the reaction mixture into a separatory funnel and add a small amount of water.
   Shake the mixture vigorously, then allow it to settle.
   Draw off the lower layer and rinse the residue with a small amount of water.
   
9. Transfer the organic layer to a dry, round-bottomed flask equipped with a magnetic stirrer and a condenser.
   
10. Add a solution of NaI in water to the organic layer, stirring constantly.
    The concentration of the NaI solution should be approximately 5-10 M.
    
11. Continue stirring the mixture for several hours, until the reaction is complete.
    This can be determined by TLC or HPLC analysis.
    
12. Pour the reaction mixture into a separatory funnel and add a small amount of water.
    Shake the mixture vigorously, then allow it to settle.
    Draw off the lower layer and rinse the residue with a small amount of water.
    
13. Transfer the organic layer to a dry, round-bottomed flask equipped with a magnetic stirrer and a condenser.
    
14. Add a solution of Na2CO3 in water to the organic layer, stirring constantly.
    The concentration of the Na2CO3 solution should be approximately 5-10 M.
    
15. Continue stirring the mixture for several hours, until the reaction is complete.
    This can be determined by TLC or HPLC analysis.
    
16. Pour the reaction mixture into a separatory funnel and add a small amount of water.
    Shake the mixture vigorously, then allow it to settle.
    Draw off the lower layer and rinse the residue with a small amount of water.
    
17. Transfer the organic layer to a dry, round-bottomed flask equipped with a magnetic stirrer and a condenser.
    
18. Add a solution of MgSO4 in water to the organic layer, stirring constantly.
    The concentration of the MgSO4 solution should be approximately 5-10 M.
    
19. Continue stirring the mixture for several hours, until the reaction is complete.
    This can be determined by TLC or HPLC analysis.
    
20. Pour the reaction mixture into a separatory funnel and add a small amount of water.
    Shake the mixture vigorously, then allow it to settle.
    Draw off the lower layer and rinse the residue with a small amount of water.
    
21. Transfer the organic layer to a dry, round-bottomed flask equipped with a magnetic stirrer and a condenser.
    
22. Add a solution of NaCl in water to the organic layer, stirring constantly.
    The concentration of the NaCl