The Instruction of 4-CHLOROPYRIDAZINE

4-Chloropyridazine is an important intermediate chemical in the chemical industry.
It is widely used as a building block for the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and other specialty chemicals.
The instructions for handling and using 4-chloropyridazine must be followed carefully to ensure the safety of workers and the environment.

2.
1 General Information

2.
1.
1 Description
4-Chloropyridazine is a white crystalline solid with a slightly sweet odor.
It is highly soluble in water and organic solvents.
It is a toxic compound and must be handled with caution.

2.
1.
2 Physical and Chemical Properties
The physical and chemical properties of 4-chloropyridazine are as follows:

• Melting point: 178-180°C
• Boiling point: 270-271°C
• Density: 1.
  58 g/cm3
• Solubility: highly soluble in water and organic solvents
• Log P: 3.
  03 (octanol-water partition coefficient)
• pH: 10 (approx.
  )
• Viscosity: 35 cm3/g (measured at 25°C)

2.
2 Hazard Identification

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2.
1 Health Hazards
4-Chloropyridazine is a toxic compound and exposure to it can cause skin irritation, respiratory problems, and digestive system problems.
It is also a suspected human carcinogen.

2.
2.
2 Fire and Explosion Hazards
4-Chloropyridazine is not particularly prone to fire or explosion.
However, if it is involved in a fire, it should be allowed to burn out slowly.
Firefighters should be trained in the proper handling of chemical fires.

2.
3 Handling and Storage

2.
3.
1 Handling
Workers handling 4-chloropyridazine must wear appropriate personal protective equipment, including gloves, safety glasses or goggles, and a lab coat.
Contact with the skin should be avoided.
In case of contact with the skin or eyes, seek medical attention immediately.
Measures should be taken to prevent the spread of dust or vapor.

2.
3.
2 Storage
4-Chloropyridazine should be stored in a cool, dry, and well-ventilated area.
It should be stored away from sources of ignition, such as heat lamps or hot plates.
It should be stored in an area that is accessible only to authorized personnel.
It should be stored in a secure location to prevent unauthorized access.

2.
4 Environmental Considerations

2.
4.
1 Disposal
4-Chloropyridazine should be disposed of in accordance with local, state, and federal regulations.
It should be disposed of in a manner that does not pose a risk to human health or the environment.

2.
4.
2 Spill and Leakage Procedures
In case of a spill or leakage, the area should be evacuated immediately.
The spill should be contained as much as possible and the appropriate clean-up procedures should be followed.

3. TECHNICAL INFORMATION
   3.
   1 Synthesis
   4-Chloropyridazine can be synthesized by a number of methods.
   One common method is the chlorination of pyridazine with chlorine gas.
   The reaction is as follows:

C4H6N2 + Cl2 → C4H4Cl2N2

Another method is the reaction of 4-nitropyridine with potassium hydroxide.
The reaction is as follows:

C4H4N2O + KOH → C4H4Cl2N2 + H2O

3.
2 Applications

4-Chlor