The Instruction of Ethyl-5-bromopyrimidine-2-carboxylate

Ethyl 5-bromopyrimidine-2-carboxylate is an organic compound that is commonly used in the chemical industry as a raw material for the production of a range of chemicals, drugs, and other products.
The compound is typically synthesized through a multi-step process that involves the use of various chemical reagents and catalysts.

One of the most common methods of synthesizing Ethyl 5-bromopyrimidine-2-carboxylate involves the use of water as a solvent and potassium hydroxide as a catalyst.
The reaction involves the treatment of 5-bromo-2-nitro-1H-pyrimidine with ethyl bromide in the presence of water and potassium hydroxide.
The reaction proceeds through a sequence of steps, including the formation of ethyl nitrite, which then undergoes a diazotization reaction to form ethyl hydrazide.
The hydrazide is then converted into a carboxylate through a reaction with carbon dioxide, which is liberated from ethylene carbonate.
The resulting carboxylate is then treated with sodium chloride to remov