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Ethyl 6-chloro-3-hydroxypyridazine-4-carboxylate is an important intermediate in the synthesis of various pharmaceuticals and agrochemicals.
It is also used as a starting material for the production of other chemicals.
The instruction of ethyl 6-chloro-3-hydroxypyridazine-4-carboxylate involves several steps, which are outlined below.
Step 1: Synthesis of 6-chloro-3-nitropyridazine-4-carboxylic acid
The synthesis of 6-chloro-3-nitropyridazine-4-carboxylic acid involves the reaction of chloroform with nitrous acid.
The reaction is carried out in the presence of sodium hydroxide to improve the yield.
The product is then treated with a solution of sodium hydroxide and the resulting precipitate is filtered and washed with water.
The crude product is then purified by recrystallization.
Step 2: Synthesis of 6-chloro-3-hydroxypyridazine-4-carboxylic acid
The synthesis of 6-chloro-3-hydroxypyridazine-4-carboxylic acid involves the reduction of 6-chloro-3-nitropyridazine-4-carboxylic acid using hydrogen in the presence of a catalyst such as palladium on barium sulfate.
The reduction is carried out at a low temperature and the product is then purified by recrystallization.
Step 3: Synthesis of ethyl 6-chloro-3-hydroxypyridazine-4-carboxylate
The synthesis of ethyl 6-chloro-3-hydroxypyridazine-4-carboxylate involves the esterification of 6-chloro-3-hydroxypyridazine-4-carboxylic acid with ethanol in the presence of a catalyst such as sodium hydroxide.
The product is then purified by recrystallization.
Overall, the instruction of ethyl 6-chloro-3-hydroxypyridazine-4-carboxylate involves several steps, which are outlined above.
The synthesis of the intermediate is an important step in the production of various chemicals and pharmaceuticals and requires careful control of the reaction conditions to ensure the desired yield and purity.
The intermediate is typically used as a starting material for the production of other chemicals and is an important building block in the synthesis of many pharmaceuticals and agrochemicals.