The José C. Pastor-Pareja research team of the School of Life Sciences solved the decades-old mystery of how insect wings flatten

"All things grow by the sun, and fruit flies rely on their wings to fly

The José C.

In addition, the researchers also found that the abnormal development of Drosophila caused the two layers of cells in the wings to be separated due to internal pressure, forming long cable-like protrusions at the atypical laminin spots.

In order to further study how cable-like cytoskeletal protrusions assemble and disaggregate, the Pastor-Pareja research group carried out genetic screening experiments for cytoskeleton-related proteins in Drosophila wings

For the first time, this research work unified the dynamic changes of cells and extracellular matrix during the wing fitting process, discovered the necessary role of atypical laminin in the process of wing morphogenesis, and revealed the atypical layer The important evolutionary significance of cohesion between adhesion protein and matrix-cytoskeleton in the process of wing fitting

Link to the paper: https://

Further reading:

[1] The genetic control of wing development in Drosophila.

Waddington CH.

J Genet (1940) 41: 75-113.

[2] The pupal contraction as an epigenetic crisis in Drosophila.

Waddington CH.

Proc Zool Soc Lond (1942) A111: 181-188.

[3] A screen to identify Drosophila genes required for integrin-mediated adhesion.

Walsh EP, Brown NH.

Genetics (1998) 150: 791-805.

[4] Atypical basement membranes and basement membrane diversity – what is normal anyway?

Pastor-Pareja JC.

J Cell Sci (2020) 133: jcs241794.

https://doi.
org/10.
1242/jcs.
241794

[5] Atypical laminin spots and pull-generated microtubule-actin projections mediate Drosophila wing adhesion.

Sun T, Song Y, Teng D, Chen Y, Dai J, Ma M, Zhang W, Pastor-Pareja JC.

Cell Rep (2021) 36: 109667.

https://doi.
org/10.
1016/j.
celrep.
2021.
109667

José C.
Pastor-Pareja Laboratory:

http://joselab.
life.
tsinghua.
edu.
cn