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This article is original by Translational Medicine.
Please indicate the source for reprinting.
Author: Tiffany Guide: In October 2021, intensified vaccination in many provinces and cities in China continued to spread
.
As of October 12, the areas where intensive vaccination has been initiated involve at least 12 provinces, namely Heilongjiang, Shanxi, Shandong, Chongqing, Hunan, Hubei, Yunnan, Guizhou, Guangxi, Anhui, Fujian, and Hainan
.
In foreign countries, the scientific community is also very concerned about the effectiveness of strengthening needles, and many studies and experiments have been carried out
.
Recently, the world’s largest study conducted in Israel led by Harvard University confirmed the effectiveness of the new crown booster needle.
What enlightenment this will give people.
.
.
Since October 17, there have been many local outbreaks in China.
It is developing rapidly and has spread to 11 provinces within a week
.
Most of the infected people have cross-regional travel activities, and the risk of further spread of the epidemic is still increasing
.
In the context of the new round of the epidemic, many places have successively initiated the inoculation of the new crown vaccine booster for key populations
.
According to the analysis of research results at home and abroad, the effect of preventing infection after vaccination, especially the prevention of severe illness and death, is relatively significant
.
But as time goes by, the level of neutralizing antibodies of the recipient is decreasing, and the protective effect is weakening
.
Initiating the booster vaccination at the right time is actually a preventive relay behavior, which plays an important role in consolidating the effect of the previous vaccination
.
Recently, local confirmed cases have reappeared in many places across the country, and with the advent of autumn and winter, the epidemic is on the rise again
.
In this context, the advancement of intensified vaccination is tantamount to adding another line of defense for effective epidemic prevention
.
This is also a full consideration for the life safety and physical health of the people
.
In foreign countries, scientists have also conducted extensive research to explore how strong the protective effect of enhanced needles is
.
After inoculation with the booster shot, what is the resistance he brought to us against the mutant virus? Take a look at the research conducted by this group of scientists
.
The Clalit Institute cooperated with researchers from Harvard University.
They conducted an experiment to study and analyze the effectiveness of Pfizer's BNT162B2 booster shot against the new coronavirus variant Delta, which is the world's largest comprehensive health One of the record databases
.
Their study was conducted in Israel.
The study conducted the largest peer-reviewed evaluation of the effectiveness of the third dose of the new crown vaccine (ie booster shot) in the national mass vaccination environment, and then these scientists evaluated them The research results were published in an article titled "Effectiveness of a third dose of the BNT162b2 mRNA COVID-19 vaccine for preventing severe outcomes in Israel: an observational study" in The Lancet: Although vaccination has been A certain degree of success has been achieved, but the new crown epidemic in many countries is currently resurgence
.
This may be because the mutant virus Delta is more contagious, and the immunity of people vaccinated a few months ago has decreased, which has caused the people who were vaccinated to also be infected with Delta virus
.
Facing the current trend of the resurgence of the new crown epidemic, some countries are planning to implement the mRNA-COVID-19 vaccine booster
.
This study shows that compared with people who received two doses of the vaccine at least 5 months ago, booster injections are effective in reducing the results related to severe COVID-19
.
This is the first time that the scientific community has strengthened the evaluation of the effectiveness of the mRNA-COVID-19 vaccine (BNT162b2) in the prevention of severe new coronary diseases.
They have carried out a more detailed evaluation by adjusting various possible confounding factors, including comorbidities and behavioral factors.
Analysis
.
The large experimental sample size of this research also allows scientists to more accurately evaluate vaccines in different periods, different subpopulations (by gender, age, and number of comorbidities), and different serious outcomes (this situation is relatively rare, so larger Sample size)
.
Prior to this large-scale study, the last time BioNTech conducted a clinical trial had a small sample size, and did not estimate the impact of the booster dose on severe COVID-19
.
The study was conducted from July 30, 2021 to September 23, 2021, at the time when the fourth wave of COVID-19 in Israel was raging.
During this period, the Delta (B.
1.
617.
2) mutant virus was infected by the country’s new crown.
The main strain, at that time, almost all patients with COVID-19 in Israel were infected by the Delta mutant virus
.
In this study, the scientists analyzed and studied the data of 728,321 people who were 12 years old or older who had been vaccinated with BNT162b2 booster shots; in addition, they also arranged another group of people with at least 5 It is composed of people who have only received two doses of BNT162b2 vaccine a month ago.
The number of people in these two groups is equal, 728,321 people
.
Their 1:1 matching method is based on a broad set of demographic, geographic, and health-related attributes related to infection risk, serious disease risk, health status, and medical seeking behavior
.
These individuals were dynamically assigned to each group based on changes in their vaccination status (198,476 people who were transferred from the unvaccinated cohort to the vaccinated cohort during the study period)
.
Scientists have performed multiple analyses on them to ensure that the final vaccine effectiveness data can withstand potential biases
.
The study conducted daily follow-ups on more than 12 million people
.
They compared the test data of these two groups of people, and the results showed that compared with those who had received two doses of the vaccine only 5 months ago, those who had received the booster shot (7 days or more since the date of vaccination) Long-term) have stronger resistance to the new crown virus, their risk of hospitalization has been reduced by 93%, their risk of severe illness from the new crown has been reduced by 92%, and the risk of death by 81%
.
The study found that the effectiveness of vaccines for different genders, ages (40-69 years and over 70) and the number of comorbidities was similar
.
The study also included a population-level analysis.
According to the analysis, the probability of infection of the new crown in each age group began to decline 7-10 days after the new crown booster shot in that age group
.
Professor Ran Balicer, the senior author of the study, the director of the Clalit Institute and the chief innovation officer, said: "These results are very convincing: starting one week after people receive the booster shot, it affects different age groups and population subgroups.
The results related to the severe disease of the new crown are very effective
.
These data can also help government agencies in various countries to make more informed decisions, such as: promoting people's vaccination and strengthening injections, and so on
.
"Boston Children's Hospital Computational Health Informatics Project and Harvard Medical School Predictive Medicine The team’s director, Professor Ben Reis, said, “So far, information on vaccine effectiveness is still lacking.
This is one of the main reasons why people are still hesitant to vaccination
.
This careful epidemiological study is The effectiveness of the third dose of the vaccine provides reliable information.
We hope that the results of this research and the conclusions we have drawn will help those who have not yet received the booster shot to get rid of their doubts and get vaccinated as soon as possible
.
"Reference material: https://medicalxpress.
com/news/2021-10-largest-real-world-dose-covid-vaccine.
html Note: This article is intended to introduce medical research progress and cannot be used as a reference for treatment plans
.
If needed For health guidance, please go to a regular hospital for treatment
.
Popular·Article Cancer Conference [Announcement of the full schedule] The 3rd Shanghai International Cancer Conference, you are cordially invited to participate! Cancer Conference [Guests Announced] More than 160 celebrities gathered in the 3rd Shanghai International Conference on Cancer, welcome to attend! Cancer research [Nature] Breakthrough! Stem cell technology and next-generation DNA sequencing discovered the most common and refractory brain tumor-a new therapeutic target gene editing for glioblastoma multiforme [Cell blockbuster] New research on DNA repair has promoted the development of CRISPR-Cas9 gene editing technology, as well as the development of the lead editing technology developed by the team of gene editing Daniel Liu Ruqian [JAHA] The side effects of "space travel" that astronauts must bear—— The DNA deletion in the mitochondria of the "energy factory of the cell" will lay the foundation for research to avoid the risk of manned spaceflight! Gene sequencing [heavy] published 9 preprints in a row: Whole genome sequencing found 13 genomic mutations of drug-resistant tuberculosis, Draw the most comprehensive map of drug resistance genes in tuberculosis so far! Immunotherapy [Science Sub-Journal] The team of Academician Tian Zhigang of the Chinese Academy of Sciences discovered innate immune cells and a new checkpoint molecule for anti-tumor immunity.
The new coronavirus [NEJM] is also COVID-19.
What is the difference between vaccines? Scientists use data to tell you the truth! Under the COVID-19 envelope, are the competing stem cell therapies really effective? There may be a lack of clinical trials and scientific proofs.
Please indicate the source for reprinting.
Author: Tiffany Guide: In October 2021, intensified vaccination in many provinces and cities in China continued to spread
.
As of October 12, the areas where intensive vaccination has been initiated involve at least 12 provinces, namely Heilongjiang, Shanxi, Shandong, Chongqing, Hunan, Hubei, Yunnan, Guizhou, Guangxi, Anhui, Fujian, and Hainan
.
In foreign countries, the scientific community is also very concerned about the effectiveness of strengthening needles, and many studies and experiments have been carried out
.
Recently, the world’s largest study conducted in Israel led by Harvard University confirmed the effectiveness of the new crown booster needle.
What enlightenment this will give people.
.
.
Since October 17, there have been many local outbreaks in China.
It is developing rapidly and has spread to 11 provinces within a week
.
Most of the infected people have cross-regional travel activities, and the risk of further spread of the epidemic is still increasing
.
In the context of the new round of the epidemic, many places have successively initiated the inoculation of the new crown vaccine booster for key populations
.
According to the analysis of research results at home and abroad, the effect of preventing infection after vaccination, especially the prevention of severe illness and death, is relatively significant
.
But as time goes by, the level of neutralizing antibodies of the recipient is decreasing, and the protective effect is weakening
.
Initiating the booster vaccination at the right time is actually a preventive relay behavior, which plays an important role in consolidating the effect of the previous vaccination
.
Recently, local confirmed cases have reappeared in many places across the country, and with the advent of autumn and winter, the epidemic is on the rise again
.
In this context, the advancement of intensified vaccination is tantamount to adding another line of defense for effective epidemic prevention
.
This is also a full consideration for the life safety and physical health of the people
.
In foreign countries, scientists have also conducted extensive research to explore how strong the protective effect of enhanced needles is
.
After inoculation with the booster shot, what is the resistance he brought to us against the mutant virus? Take a look at the research conducted by this group of scientists
.
The Clalit Institute cooperated with researchers from Harvard University.
They conducted an experiment to study and analyze the effectiveness of Pfizer's BNT162B2 booster shot against the new coronavirus variant Delta, which is the world's largest comprehensive health One of the record databases
.
Their study was conducted in Israel.
The study conducted the largest peer-reviewed evaluation of the effectiveness of the third dose of the new crown vaccine (ie booster shot) in the national mass vaccination environment, and then these scientists evaluated them The research results were published in an article titled "Effectiveness of a third dose of the BNT162b2 mRNA COVID-19 vaccine for preventing severe outcomes in Israel: an observational study" in The Lancet: Although vaccination has been A certain degree of success has been achieved, but the new crown epidemic in many countries is currently resurgence
.
This may be because the mutant virus Delta is more contagious, and the immunity of people vaccinated a few months ago has decreased, which has caused the people who were vaccinated to also be infected with Delta virus
.
Facing the current trend of the resurgence of the new crown epidemic, some countries are planning to implement the mRNA-COVID-19 vaccine booster
.
This study shows that compared with people who received two doses of the vaccine at least 5 months ago, booster injections are effective in reducing the results related to severe COVID-19
.
This is the first time that the scientific community has strengthened the evaluation of the effectiveness of the mRNA-COVID-19 vaccine (BNT162b2) in the prevention of severe new coronary diseases.
They have carried out a more detailed evaluation by adjusting various possible confounding factors, including comorbidities and behavioral factors.
Analysis
.
The large experimental sample size of this research also allows scientists to more accurately evaluate vaccines in different periods, different subpopulations (by gender, age, and number of comorbidities), and different serious outcomes (this situation is relatively rare, so larger Sample size)
.
Prior to this large-scale study, the last time BioNTech conducted a clinical trial had a small sample size, and did not estimate the impact of the booster dose on severe COVID-19
.
The study was conducted from July 30, 2021 to September 23, 2021, at the time when the fourth wave of COVID-19 in Israel was raging.
During this period, the Delta (B.
1.
617.
2) mutant virus was infected by the country’s new crown.
The main strain, at that time, almost all patients with COVID-19 in Israel were infected by the Delta mutant virus
.
In this study, the scientists analyzed and studied the data of 728,321 people who were 12 years old or older who had been vaccinated with BNT162b2 booster shots; in addition, they also arranged another group of people with at least 5 It is composed of people who have only received two doses of BNT162b2 vaccine a month ago.
The number of people in these two groups is equal, 728,321 people
.
Their 1:1 matching method is based on a broad set of demographic, geographic, and health-related attributes related to infection risk, serious disease risk, health status, and medical seeking behavior
.
These individuals were dynamically assigned to each group based on changes in their vaccination status (198,476 people who were transferred from the unvaccinated cohort to the vaccinated cohort during the study period)
.
Scientists have performed multiple analyses on them to ensure that the final vaccine effectiveness data can withstand potential biases
.
The study conducted daily follow-ups on more than 12 million people
.
They compared the test data of these two groups of people, and the results showed that compared with those who had received two doses of the vaccine only 5 months ago, those who had received the booster shot (7 days or more since the date of vaccination) Long-term) have stronger resistance to the new crown virus, their risk of hospitalization has been reduced by 93%, their risk of severe illness from the new crown has been reduced by 92%, and the risk of death by 81%
.
The study found that the effectiveness of vaccines for different genders, ages (40-69 years and over 70) and the number of comorbidities was similar
.
The study also included a population-level analysis.
According to the analysis, the probability of infection of the new crown in each age group began to decline 7-10 days after the new crown booster shot in that age group
.
Professor Ran Balicer, the senior author of the study, the director of the Clalit Institute and the chief innovation officer, said: "These results are very convincing: starting one week after people receive the booster shot, it affects different age groups and population subgroups.
The results related to the severe disease of the new crown are very effective
.
These data can also help government agencies in various countries to make more informed decisions, such as: promoting people's vaccination and strengthening injections, and so on
.
"Boston Children's Hospital Computational Health Informatics Project and Harvard Medical School Predictive Medicine The team’s director, Professor Ben Reis, said, “So far, information on vaccine effectiveness is still lacking.
This is one of the main reasons why people are still hesitant to vaccination
.
This careful epidemiological study is The effectiveness of the third dose of the vaccine provides reliable information.
We hope that the results of this research and the conclusions we have drawn will help those who have not yet received the booster shot to get rid of their doubts and get vaccinated as soon as possible
.
"Reference material: https://medicalxpress.
com/news/2021-10-largest-real-world-dose-covid-vaccine.
html Note: This article is intended to introduce medical research progress and cannot be used as a reference for treatment plans
.
If needed For health guidance, please go to a regular hospital for treatment
.
Popular·Article Cancer Conference [Announcement of the full schedule] The 3rd Shanghai International Cancer Conference, you are cordially invited to participate! Cancer Conference [Guests Announced] More than 160 celebrities gathered in the 3rd Shanghai International Conference on Cancer, welcome to attend! Cancer research [Nature] Breakthrough! Stem cell technology and next-generation DNA sequencing discovered the most common and refractory brain tumor-a new therapeutic target gene editing for glioblastoma multiforme [Cell blockbuster] New research on DNA repair has promoted the development of CRISPR-Cas9 gene editing technology, as well as the development of the lead editing technology developed by the team of gene editing Daniel Liu Ruqian [JAHA] The side effects of "space travel" that astronauts must bear—— The DNA deletion in the mitochondria of the "energy factory of the cell" will lay the foundation for research to avoid the risk of manned spaceflight! Gene sequencing [heavy] published 9 preprints in a row: Whole genome sequencing found 13 genomic mutations of drug-resistant tuberculosis, Draw the most comprehensive map of drug resistance genes in tuberculosis so far! Immunotherapy [Science Sub-Journal] The team of Academician Tian Zhigang of the Chinese Academy of Sciences discovered innate immune cells and a new checkpoint molecule for anti-tumor immunity.
The new coronavirus [NEJM] is also COVID-19.
What is the difference between vaccines? Scientists use data to tell you the truth! Under the COVID-19 envelope, are the competing stem cell therapies really effective? There may be a lack of clinical trials and scientific proofs.
