The Lancet sub-| A prospective study of the British Biological Sample Bank: The relationship between physical weakness and the onset of dementia

Alzheimer's disease, or AD for short, is the most common pathological type of dementia in old age.
Early to obvious memory decline mainly, gradually lose the ability of daily life, and accompanied by mental symptoms and behavior disorders, the disease showed sexual progression, late often appear swallowing difficulties, bedridden, the onset of about 10 years, often due to infection and other complications of death.
according to a report released by the International Alzheimer's Association, there are about 50 million people living with Alzheimer's worldwide in 2018, with an average of one elderly person diagnosed with alzheimer's disease every three seconds.
there are now more than 50 million people with dementia and cognitive impairment in China, according to Data published last year by Professor Jia Jianping's team at Xuanwu Hospital in Lancet Neurology.
, the number of people with dementia has exceeded 10 million.
, given that current drug interventions are not yet curable or reverse dementia, identifying potential risk factors for dementia and making early interventions is an important way to prevent disease progression.
a 2020 report, intervention with 12 risk factors for dementia can prevent or delay the onset of dementia by 40 percent.
, physical weakness is one of the risk factors.
is a condition that can easily affect physical health, including hospitalization and death.
studies have shown that weakness is associated with poor prognostics, cardiovascular disease, and even hospital deaths in patients with neo-coronary pneumonia.
the link between such weakness and the onset of dementia? Researchers at the University of Glasgow in the UK carried out the study.
results were published in the Lancet journal Lancet Healthy Longev.
the prospective study included participants in the UK biological sample pool who were at risk of developing dementia but did not have any form of dementia at baseline.
use an improved scale of weakness to define weakness.
5 individual items (weight loss, fatigue, physical activity, gait speed, and grip strength).
is classified as a pre-debilitating state if one or two criteria are met, or as a debilitating state if three or more criteria are met.
502,535 participants were screened, of whom 143,215 were included in the study.
68,500 participants (47.8%) were in pre-weakness states and 5,565 (3.9%) were weak.
726 people developed dementia during a 5.4-year mid-year follow-up period.
in a fully adjusted model, pre-weakness (HR=1.21) and weakness (HR=1.98) increased the risk of dementia compared to non-weak people.
of the five components used to define weakness, weight loss, fatigue, low grip and slow gait increased the risk of dementia by 31%, 48%, 38% and 55%, respectively.
population attribution analysis, pre-weakness and weakness accounted for 9.9% and 8.6% of dementia cases, respectively, in the study sample.
shows that both pre-weakness and weakness increase the risk of dementia.
early screening and dare to be weak or prevent or delay the onset of dementia.
: Associations between physical frailty and dementia rates: a prospective study from UK Biobank. Lancet healthy longevity. (2020). DOI: MedSci Original Source: MedSci Original Copyright Notice: All text, images and audio and video materials on this website that indicate "Source: Metz Medicine" or "Source: MedSci Original" are owned by Metz Medicine and are not authorized to be reproduced by any media, website or individual, and must be reproduced with the words "Source: Mets Medicine".
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