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*For medical professionals only
FlaURA study confirmed the remarkable efficacy and good safety of osimtinib in the first-line treatment of EGFR mutation-positive advanced NSCLC, FLOURISH research further demonstrated the efficacy and safety of osimtinib first-line treatment in the real world in China, providing more comprehensive and more complete evidence of first-line treatment of osimtinib in patients with positive EGFR mutations in advanced NSCLC in China, and we believe that oshitinib as the first-line standard treatment of this population will benefit more Chinese patients
。
*Deadline2022-9-12Inscienter
Profile
Zhou Jianya Professor, Doctoral Supervisor, Chief Physician; Deputy Director of the Department of Respiratory Medicine, The First Affiliated Hospital of Zhejiang University School of Medicine (presided over the work); Director of Zhejiang Clinical Research Center for Respiratory Diseases; Director of the Chinese Society of Clinical Oncology (CSCO), member of the Special Committee on Non-small Cell Lung Cancer; Member of tobacco disease group of respiratory branch of Chinese Medical Association, member of medical ethics branch group; Member of Respiratory Branch of Zhejiang Medical Association; Member of the Lung Cancer Committee of Zhejiang Anti-Cancer Association, Standing Committee Member of the Tumor Marker Committee; Inspector of new drugs of the State Food and Drug Administration; Visiting Scholar, Sidney Kimmel Cancer Center, Johns Hopkins Hospital, USA; He has presided over 3 national natural science foundations, published more than 10 SCI papers by the first author, and participated in a number of international multi-center clinical trials
.
New progress and prospect of targeted therapy for lung cancer[J].
Chinese Journal of Oncology, 2020,30(10):733-743.
[2] Soria JC, Ohe Y, Vansteenkiste J, et al.
Osimertinib in Untreated EGFR-Mutated Advanced Non-Small-Cell Lung Cancer.
N Engl J Med.
2018 Jan 11; 378(2):113-125.
[3] Reungwetwattana T, Nakagawa K, Cho BC, et al.
CNS Response to Osimertinib Versus Standard Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Patients With Untreated EGFR-Mutated Advanced Non-Small-Cell Lung Cancer.
J Clin Oncol.
2018 Aug 28:JCO2018783118.
[4]S.
S.
Ramalingam, J.
E.
Gray, Y.
Ohe, et al.
Osimertinib vs comparator EGFR-TKI as first-line treatment for EGFRm advanced NSCLC (FLAURA): Final overall survival analysis.
Annals of Oncology (2019) 30 (suppl_5): v851-v934.
[5] Cheng Y, He Y, Li W, et al.
Osimertinib Versus Comparator EGFR TKI as First-Line Treatment for EGFR-Mutated Advanced NSCLC: FLAURA China, A Randomized Study.
Target Oncol.
2021 Mar; 16(2):165-176.
[6] Jianying Zhou, Jianya Zhou, Jing Zheng, et al.
Real-World Outcomes of First-Line Osimertinib for EGFR Mutated Advanced NSCLC Patients in China: Interim Analysis of FLOURISH Study.
2022ESMO 1123P.
* This article is for the sole purpose of providing scientific information to medical professionals and does not represent the views of this platform
Prospective SOURCE STUDIES add strong evidence
FlaURA study confirmed the remarkable efficacy and good safety of osimtinib in the first-line treatment of EGFR mutation-positive advanced NSCLC, FLOURISH research further demonstrated the efficacy and safety of osimtinib first-line treatment in the real world in China, providing more comprehensive and more complete evidence of first-line treatment of osimtinib in patients with positive EGFR mutations in advanced NSCLC in China, and we believe that oshitinib as the first-line standard treatment of this population will benefit more Chinese patients
。
*Deadline2022-9-12Inscienter
Profile
Zhou Jianya Professor, Doctoral Supervisor, Chief Physician; Deputy Director of the Department of Respiratory Medicine, The First Affiliated Hospital of Zhejiang University School of Medicine (presided over the work); Director of Zhejiang Clinical Research Center for Respiratory Diseases; Director of the Chinese Society of Clinical Oncology (CSCO), member of the Special Committee on Non-small Cell Lung Cancer; Member of tobacco disease group of respiratory branch of Chinese Medical Association, member of medical ethics branch group; Member of Respiratory Branch of Zhejiang Medical Association; Member of the Lung Cancer Committee of Zhejiang Anti-Cancer Association, Standing Committee Member of the Tumor Marker Committee; Inspector of new drugs of the State Food and Drug Administration; Visiting Scholar, Sidney Kimmel Cancer Center, Johns Hopkins Hospital, USA; He has presided over 3 national natural science foundations, published more than 10 SCI papers by the first author, and participated in a number of international multi-center clinical trials
.
References:
[1] Hong Shaodong, Zhang Li.New progress and prospect of targeted therapy for lung cancer[J].
Chinese Journal of Oncology, 2020,30(10):733-743.
[2] Soria JC, Ohe Y, Vansteenkiste J, et al.
Osimertinib in Untreated EGFR-Mutated Advanced Non-Small-Cell Lung Cancer.
N Engl J Med.
2018 Jan 11; 378(2):113-125.
[3] Reungwetwattana T, Nakagawa K, Cho BC, et al.
CNS Response to Osimertinib Versus Standard Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Patients With Untreated EGFR-Mutated Advanced Non-Small-Cell Lung Cancer.
J Clin Oncol.
2018 Aug 28:JCO2018783118.
[4]S.
S.
Ramalingam, J.
E.
Gray, Y.
Ohe, et al.
Osimertinib vs comparator EGFR-TKI as first-line treatment for EGFRm advanced NSCLC (FLAURA): Final overall survival analysis.
Annals of Oncology (2019) 30 (suppl_5): v851-v934.
[5] Cheng Y, He Y, Li W, et al.
Osimertinib Versus Comparator EGFR TKI as First-Line Treatment for EGFR-Mutated Advanced NSCLC: FLAURA China, A Randomized Study.
Target Oncol.
2021 Mar; 16(2):165-176.
[6] Jianying Zhou, Jianya Zhou, Jing Zheng, et al.
Real-World Outcomes of First-Line Osimertinib for EGFR Mutated Advanced NSCLC Patients in China: Interim Analysis of FLOURISH Study.
2022ESMO 1123P.
* This article is for the sole purpose of providing scientific information to medical professionals and does not represent the views of this platform