The latest news and research results in the industry.
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Last Update: 2020-08-30
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Source: Internet
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Author: User
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. . . . . . . . . . . . . . . . . .. . . . . . . . . . Probiotics can reverse the mental damage that patrilineal stress can cause to future generations
taking young mice away from their mothers can cause mental harm and mental illness in adulthood, and these effects can be passed on to the next generation. New research suggests that probiotics can reverse the damage of this generational transmission.
scientists from the University of New South Wales, Columbia University and the University of Melbourne are now reporting that giving probiotics to the first generation of children can stop mental harm from passing on to their offspring. The probiotics used in the trial were Lacidofil, containing 95 per cent lactobacillus lactobacillus lactobacillus lactobacillus lactobacillus lactobacillus lactobacillus lactobacillus R0011 and 5 per cent Swiss lactobacillus R0052 (Lallemand Health Solutions).
adversity in early childhood is a powerful risk factor for individual mental health disorders, and the effects of adversity on individuals can spread from generation to generation, and these adversity is also associated with poor gastrointestinal conditions. In addition, new evidence suggests that microbiome-brain-intestinal interactions can regulate the effects of early childhood stress on mental disorders.
the new study covered three generations of about 400 mice, performing early stressors (such as mother-to-child separation) on infant male mice, and studying the aversion responses of their offspring under stress-source conditions.
first generation (F0), the MS group consisted of animals separated from their mothers 2 to 14 days after birth, and the SR group consisted of animals that weaned 21 to 23 days after birth, with male animals further divided into groups, some taking probiotics for 12 days and some not. Females then mate with the first generation of males to give birth to the second generation (F1). The results showed that the second-generation males in the MS group had a longer aversion response and a higher recurrence rate than the offspring of the non-MS group. These data are the first to confirm that behavioral changes caused by stress can be inherited into future generations. The F1 generation of young mice took probiotic therapy and the F0 generation of parents took probiotics for preventive treatment, and the results showed that the intervention of probiotics was associated with a reversal of the effects of these generations.
FDA Releases Draft Guidance on Nutrition Label compliance
The FDA issued a draft guidance on Nutrition Label Compliance Q and A on January 5, 2017, allowing companies to submit recommendations and comments electronically or in writing within 60 days.
this guidance document applies to regular food and dietary supplement manufacturers and provides a question and answer on compliance with Food Labels: New Nutrition and Supplement Labels. FDA2016527,:
"Calories from fat"();
"added sugars"()(),(DRV)(DV),%DV;
"Sugars"()"Total Sugars"(),"Total Sugars";
;
%DV;
;
。 There is no need to include a reference nutritional value of a nutrient in a diet containing 2,
000 to 2,500 calories in a footnote to the table;
To supplement the definition of a single-dose container;
requires double-bar labeling of certain packages;
labeling regulations are effective on July 26, 2016, and companies are required to be compliant within two years of the new rules, i.e. July 26, 2018; and manufacturers with annual food sales of less than $10 million are required to be compliant three years after they take effect, july 26, 2019.
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Q: Do all foods sold after July 26, 2018 (after July 26, 2019 for producers with annual food sales of less than $10 million) must have a new nutrition/supplement label?
: Products labeled on or after July 26, 2018 (manufacturers with annual food sales of less than $10 million) must comply with the new nutrition label, and the FDA does not object to the original label being labeled with a revised nutrition label before the new packaging is printed, but the label does not obscure other necessary information and is always attached to the original label during normal shipping.
: How to define "producers with annual food sales of less than $10 million"?
: The company's annual food sales refers to the total food sales, that is, including local and international. A minimum sales volume for the first three years of the company or an average sales volume of less than $10 million in the previous three years is available.
strategy for aging consumers
life expectancy for the world's richest people has risen sharply from 50 to over 75 in the last century. Life expectancy is affected by a number of factors, such as improved food supply, nutrition, hygiene and the advent of better medicines, which have led to a growing and continuing trend in older persons.
Euromonitor estimates that by 2030, at least two-thirds of adults older than 65 will be over the 1 billion mark. This large and wealthy group outlines a clear and growing market for manufacturers of products that promote healthy aging.
global market for consumer health products was about $210 billion in 2015 and is expected to rise 6 percent by 2020, according to Euromonitor International. In this market, over-the-counter (OTC) health products account for a large proportion of the target customer base for the elderly. In addition to OTC painkillers and antaics for the treatment of specific diseases, products such as omega-3 fatty acids, glucosamines, and folicillin in dietary supplement products are also popular for cardiovascular, joint and eye health.
growth in dietary supplements was very stable, with a growth rate of 4 per cent in 2015, driven by increased income from the economic recovery and increased demand for such products due to an ageing population. OTC product growth is also strong for roughly the same reasons, but more importantly, more and more prescription products are switching to over-the-counter status. Products that appeal to older people are now on the shelves of pharmacies or are available from pharmacists. This is a huge opportunity for manufacturers of consumer health products. If brand awareness and loyalty can be built within this consumer group, market share can be greatly expanded, especially for products that cater to the needs of older consumers and bring new benefits.
To create favorable conditions for consumers
there are many ways to create a product that stands out from the competition, such as those that make dosage form easier to swallow or taste better than any substitute.
existing dosage form can meet all the requirements of aging consumers is soft gelatin capsules or softgel capsules. Soft capsule mechanized production process from the invention has been 80 years of history, and has been widely accepted by the market, so consumers must be very familiar with softgels. Some products, such as fish oil supplements, are now rarely found in other dosage forms.
in softgels, the active ingredient can be dissolved in polyethyl glycol or similar oils, and if insoluble, the powdered active ingredient is suspended in the oil. Liquid dosages are more precise than solid tablet doses, so this dosage form is useful for products with very low active ingredients, such as vitamin D supplements. The shell of standard softgels consists of gelatin, water and plasticizers (glycery and sorbitol). Other ingredients can be added to modify the appearance, such as colors, shades, and flavorings. The components in the housing protection capsule are not exposed to the atmosphere, which is especially important for components that are sensitive to oxygen, humidity, or both. This is also the key to the production of fish oil products with a long shelf life, as the omega-3s produce an extremely unpleasant odor after being defeated by air oxidation acid.
of the softgel technology determines that it allows for changes in the original gelatin-based method standards. Catalent's Vegicaps capsule is a product of the development of vegetarian alternatives, replacing traditional gelatin from the skin of cattle, pigs or fish with plant polysaccharides. Not only does this product meet vegetarian and non-GMO dietary requirements, its housing is also highly heat resistant. This advantage also expands the range of compatible ingredients, such as 60-degree-C encapsulation of lacto-wood fruit, which is beyond the reach of conventional gelatin capsules.
for concentrated formulations, the soft capsule dosage form used to achieve the same intensity is approximately 30% smaller than the conventional dosage form. This is very beneficial for older people or children with dysphagy for capsules of average size and can increase the market potential of the product. This solution is provided by OptiGel Mini of Catalent.
that chewing products are a very common nutritional supplement for older consumers. There are also scattered pieces of box pectin products. The gelatin shell of The EasyBurst product, designed by Catalent, is much thinner than conventional softgels, so when chewed, the shell is easy to break and the material in the shell is easily dispersed in the mouth.
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