The latest research progress of neural stem cells (Phase 5)

News March 30, 2021/bioon.
com" target="_blank">/---Neural bioon.
com/tags/%E5%B9%B2%E7%BB%86%E8%83%9E/">stem cells are found in the nervous system and have the potential to differentiate into neurons, astrocytes and oligodendrocytes, which can produce a large number of brain cell tissues and can Carry out self-renewal, and enough to provide a large number of cell populations of brain tissue cells.
It should be noted that in all nerve tissues such as the brain and spinal cord, different neural bioon.
com/tags/%E5%B9%B2%E7%BB%86%E8%83%9E/">stem cell types produce different types of progeny cells and different distributions.
The therapeutic mechanism of neural bioon.
com/tags/%E5%B9%B2%E7%BB%86%E8%83%9E/">stem cells is: (i) After the tissue damage of the diseased part, it releases various chemokines, which can attract neural stem cells to the injured part, and differentiate into different types of cells under the action of the local microenvironment, repairing and replenishing Damaged nerve cells.
Damage to vascular endothelial cells and glial cells caused by ischemia and hypoxia increases local permeability.
In addition, under the action of a variety of adhesion molecules, neural stem cells can penetrate the blood-brain barrier and accumulate in high concentrations in the damage Location; (ii) Neural stem cells can secrete a variety of neurotrophic factors to promote the repair of damaged cells; (iii) Neural bioon.
com/course_video/gan-xi-bao-zhi-liao-ji-qi-gui-fan-hua678956.
html">stem cells can strengthen the connection between nerve synapses and establish new neural circuits.

bioon.
com" target="_blank">bioon.
com/tags/%E5%B9%B2%E7%BB%86%E8%83%9E/">Stem cell bioon.
com/tags/%E5%B9%B2%E7%BB%86%E8%83%9E/">stem cell bioon.
com/tags/%E5%B9%B2%E7%BB%86%E8%83%9E/">stem cell bioon.
com/course_video/gan-xi-bao-zhi-liao-ji-qi-gui-fan-hua678956.
html">stem cell

Problems in the application of neural stem cells: most of the established neural stem cell lines are derived from mice, and there are obvious species differences between mice and humans; the source of neural stem cells is insufficient; some of the transplanted neural stem cells develop into brain tumors; Non-selective expression of neural bioon.
com/course_video/gan-xi-bao-zhi-liao-ji-qi-gui-fan-hua678956.
html">stem cell transfection scope and in situ regulation of transfection gene expression, etc.

bioon.
com/course_video/gan-xi-bao-zhi-liao-ji-qi-gui-fan-hua678956.
html">stem cell

Based on this, the editor will take stock of the progress made in neural bioon.
com/course_video/gan-xi-bao-zhi-liao-ji-qi-gui-fan-hua678956.
html">stem cell research in recent years for readers.

bioon.
com/course_video/gan-xi-bao-zhi-liao-ji-qi-gui-fan-hua678956.
html">stem cell

1.
bioon.
com/article/6784648.
html" target="_blank">Cell Stem Cell: Up-regulating the expression of
lamin bioon.
com/article/6784648.

html" target="_blank">B1 makes aging neural stem cells rejuvenate doi:10.

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bioon.
com/article/6785034.

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Science: Mitochondria may promote the transformation of neural bioon.
com/course_video/gan-xi-bao-zhi-liao-ji-qi-gui-fan-hua678956.
html">stem cells into neuron cells during brain development .

doi:10.

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Science: Mitochondria may promote the transformation of neural bioon.
com/course_video/gan-xi-bao-zhi-liao-ji-qi-gui-fan-hua678956.

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Nature Sub-Journal: Using Stem Cell Model to Reveal New Mechanism of Fish Oil's Antidepressant
Effect doi:10.

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9.
bioon.
com/article/6749611.
html" target="_blank">Two Cell publications reveal the mechanism of
Zika bioon.
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html" target="_blank">virus invading brain stem cells, which is expected to treat deadly brain cancer doi:10.
1016/j.
celrep.
2019.
11.
020; doi:10.
1016/j.
stem.
2019.
11.
016 bioon.
com/article/6749611.
html" target="_blank">two sub-Journal cell reveals Zika virus from entering the brain mechanisms of stem cells, the use of this mechanism is expected to treat deadly brain cancer bioon.
com/course_video/gan-xi-bao-zhi-liao-ji-qi-gui-fan-hua678956.
html">stem cells, bioon.
com/course_video/gan-xi-bao-zhi-liao-ji-qi-gui-fan-hua678956.
html">stem cells

Picture from Cell Reports, 2020, doi:10.
1016/j.
celrep.
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10.
bioon.
com/article/6738819.
html" target="_blank">Nature: Neural progenitor cells from the central nervous system promote neurogenesis in cancer
doi:10.
1038/s41586-019-1219-y Autonomic nerve fibers in the tumor microenvironment regulate the initiation and spread of cancer, but the nerves are still unclear How does it appear in the bioon.
com/course_video/chang-fei-bian-ma-RNA-yu-zhong-liu959063.
html">tumor .
In a new study, French researchers found that doublecortin (DCX)-expressing neural progenitor cells (DCX + neural progenitor cells) from the central nervous system infiltrate prostate tumors and metastases, where they initiate Neurogenesis.
The relevant research results were published online in Nature on May 15, 2019, with the title of the paper "Progenitors from the central nervous system drive neurogenesis in cancer".
In a mouse model of prostate cancer, the fluctuation of DCX+ neural progenitor cells in the subventricular zone--a neurogenic area in the central nervous system--is associated with the destruction of the blood-brain barrier and the migration of DCX+ cells into the circulation.
These cells then infiltrate and stay in the prostate tumor, and are able to produce new adrenergic neurons.
In a mouse model of prostate cancer, selective bioon.
com/course_video/zhong-guo-ren-qun-ying-yang-he-yi-chuan-yin416058.
html">genetic deletion of DCX+ cells can inhibit the early stage of tumor production.
However, transplantation of DCX+ neural progenitor cells can promote bioon.
com/course_video/chang-fei-bian-ma-RNA-yu-zhong-liu959063.
html">tumor growth and metastasis.
In humans, the density of DCX+ neural progenitor cells is closely related to the aggressiveness and recurrence of prostate adenocarcinoma.
(Bioon.
com)

10.
bioon.
com/article/6738819.
html" target="_blank">Nature: Neural progenitor cells from the central nervous system promote neurogenesis in cancer
doi:10.
1038/s41586-019-1219-y bioon.
com/article/6738819.
html" target="_blank">Nature: Neural progenitor cells from the central nervous system promote neurogenesis in bioon.
com/course_video/chang-fei-bian-ma-RNA-yu-zhong-liu959063.
html">cancer Tumor bioon.
com/course_video/zhong-guo-ren-qun-ying-yang-he-yi-chuan-yin416058.
html">Genetic bioon.
com/course_video/chang-fei-bian-ma-RNA-yu-zhong-liu959063.
html">Tumor