The latest review of Nanjing Agricultural University: Virus-host interaction network as a new target for anti-IAV and anti-SARS-CoV-2 drugs

On April 27, 2022, the team of Prof.

At present, SARS-CoV-2, especially the Omicron strain, is ravaging the world, and even co-infection with IAV appears, seriously endangering human public health

The author discusses the IAV that is currently relatively mature and is expected to become the most referenced IAV for SARS-CoV-2 research in addition to members of the Coronaviridae family, and strives to quickly establish a theoretical system for virus-host interaction.

It is worth noting that the game between host antiviral innate immunity and virus antagonism host innate immunity forms a virus-host interaction network

This review was supported by the National Key R&D Program (2021YFD1800205) and the National Natural Science Foundation of China (Grant No.

About the corresponding author:

Professor Ping Jihui has long been devoted to the research on the genetic evolution, pathogenicity, cross-host transmission and related molecular mechanisms of influenza virus, molecular basis of virus antigenic variation and prediction of antigenic variation, high-yield and high-efficiency influenza vaccine and has achieved a series of innovations.

Full text link:

https:// 1 Map of antiviral drug targets focusing on the IAV replication cycle

Figure 2 Map of antiviral drug targets focusing on the host's innate immune response against IAV

Figure 3 Map of antiviral drug targets focusing on the antagonistic effect of SARS-CoV-2 on the host innate immune signaling pathway