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On August 27, 2021, the Le Yingying Research Group of the Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences published an online publication entitled "High Fat Diet and High Cholesterol Diet Reduce Hepatic Vitamin D-25-Hydroxylase" in the international academic journal Molecular Nutrition & Food Research .
Vitamin D is an essential vitamin for the human body.
Epidemiological studies have shown that people with obesity and related metabolic diseases (hyperlipidemia, insulin resistance, type 2 diabetes) have insufficient vitamin D (blood 25(OH)D 21-30 ng/ml) or lack of vitamin D (blood 25( OH)D <20 ng/ml), and vitamin D supplementation cannot effectively increase blood 25(OH)D levels
In this study, the researchers first used high-fat, high-cholesterol diet-induced obesity and glucose and lipid metabolism mouse models combined with in vitro experiments to explore the causes and mechanisms of vitamin D deficiency
The researchers further used high-fat diet-induced obesity and metabolic disorder model mice to observe whether reducing body weight and improving glucose and lipid metabolism disorders by restricting diet can improve vitamin D metabolism
In summary, the study used diet-induced obesity and glucose and lipid metabolism animal models, combined with in vitro experiments and diet restriction experiments, and found that blood cholesterol, blood sugar, and insulin increased by inhibiting liver Cyp2r1 expression led to a decrease in blood circulation 25(OH)D ; It is suggested to avoid high-fat, high-cholesterol diet, and treat obesity and glucose and lipid metabolism disorders not only to improve vitamin D metabolism and vitamin D deficiency, but also to enhance the efficacy of vitamin D supplementation by increasing liver Cyp2r1 levels
Zhu Tengfei, a doctoral student at the Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, is the first author of the paper, and researcher Le Yingying is the corresponding author
Article link: https://onlinelibrary.
