The link between Alzheimer's disease and the gut microbiome has been confirmed!

this article is original translational medicine network, reprint please indicate the sourceIntroduction: Alzheimer's disease is the most common cause of dementia, and the scientific community suspects that the gut microbiome plays a role in the development of the disease.Alzheimer's disease is the most common cause of dementia. To date, there is no cure, and it directly affects nearly 1 million people in Europe and indirectly millions of family members.recent years, the scientific community suspects that the gut microbiome plays a role in the development of disease. Recent studies have confirmed the relationship between Alzheimer's disease and the gut microbiome.study, led by the University of Geneva (UNIGE) and the University Hospital of Geneva in Switzerland, was published in the Journal of Alzheimer's disease under the title "Short-Chain Fatty Acids and Lipopolysaccharide Mediators Between Gut Dysbiosis and Amyloid Pathology in Alzheimer's Disease". This study allows us to explore a new Alzheimer's prevention strategy by regulating the microbiome of the population.A team from the University of Geneva (UNIGE) and the University Hospital of Geneva (HUG) in Switzerland, as well as the National Centre for Research and Care for Alzheimer's and Psychiatry in Brescia, the University of Naples and the IRCS SDN Research Centre in Naples, have confirmed the correlation between imbalances in the gut microbiome and the formation of amyloid plaques in the brain in humans. Amyloid plaques are the signature origin of neurodegenerative diseases in Alzheimer's disease. Certain proteins produced by gut bacteria identified in the patient's blood can indeed alter the interaction between the immune system and the nervous system, which can lead to disease.neuroscientist Giovanni Frisoni, director of the HUG Memory Center and a professor in the Department of Rehabilitation and Geriatrics at the University School of Medicine, studies the potential effects of the gut microbiome on the brain, especially on neurodegenerative diseases. He explained: "We have shown that the composition of the gut bacteri group in Alzheimer's patients has changed compared to people who do not have the disease. Their microbiome does reduce microbiobiobiology, with some bacteria overrepresented and others significantly reduced in number. In addition, we found a link between inflammation in the blood, certain gut bacteria, and Alzheimer's disease. So we wanted to test the hypothesis: Can inflammation in the blood act as a media between the microbiome and the brain?affected braingut bacteria can affect brain function and neurodegenerative changes in several ways: they affect the regulation of the immune system, which alters the interaction between the immune system and the nervous system. Lipid polysaccharin is a protein located on the bacterial membrane that has an inflammatory properties and is found around amyloid plaques and blood vessels in the brains of Alzheimer's patients. In addition, the gut microbiome produces metabolites, especially short-chain fatty acids with neuropulential and anti-inflammatory properties, which directly or indirectly affect brain function."To determine whether inflammatory media and bacterial metabolites make up the link between the Gut Microbiome and Amyloid Pathology in Alzheimer's Disease, we studied 89 people between the ages of 65 and 85. Some people suffer from Alzheimer's disease or other neurodegenerative diseases, leading to similar memory problems, while others do not have any memory problems," said Moira Marizoni, a researcher at the Frasia Fatebenefratelli Center and the first author of the work. Using PET imaging, we measured their amyloid deposits and then quantified various inflammatory markers and proteins in their blood produced by gut bacteria, such as lipid polysaccharides and short-chain fatty acids. Exclicably relevant "Our results are unquestionable: certain bacterial products of the gut microbiome are associated with the number of amyloid plaques in the brain," explains Moira Marizoni. In contrast, another high level of the short-chain fatty acid butyric acid is associated with less amyloid lesions. As , this study proves that there is a link between inflammation of certain proteins in the gut microbiome through blood inflammation and amyloid changes in the brain. Scientists will now work to identify specific bacteria or groups of bacteria associated with the phenomenon.the discovery of prevention-based strategiespaves the way for prevention strategies, such as the use of bacterial cocktails or the use of probiotics to feed "good" bacteria in the gut. However, we can't be too happy yet, friesoni said: "In fact, we first need to determine the type of cocktail." Currently, bacterial cocktails protect nerves only in the early stages of the disease, and the aim of this study is to prevent, not treat!Resources:12)