The maintenance of neurons in the cerebral cortex at specific locations in the cortex is critical to neuronal function

There are nearly tens of billions of neurons in our brain.

Studies have found that the maintenance of neurons in the cerebral cortex at a specific location in the cortex is critical to neuronal function

Neurons in the cortex are developed from neural stem cells located in the ventricular area, and these neurons migrate to specific locations in the cortex

By constructing a genetically modified mouse animal model, combining cell biology, immunohistochemical staining, brain slice culture and imaging technology, and optogenetic technology, Xie Yunli’s team discovered that the Pete Hopkins syndrome-related gene TCF4 of the autism spectrum regulates nerves.

Studies have found that when TCF4 is missing from cortical neurons, the upper neurons of the mouse cortex appear clustered, which in turn leads to neuronal dysfunction

The research work was completed under the guidance of the corresponding author Xie Yunli.

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