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The mechanism of intestinal damage caused by heat-resistant enterotoxin in pigs has been revealed

 Last Update: 2021-01-29
 Source: Internet
 Author: User

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Xiuqi, a researcher at the School of Animal Science at South China Agricultural University, revealed the mechanism by which E. coli-resistant heat-resistant enterotoxin (STp) destroys the integrity of the intestinal cortectal. The study was published online in Stem Cells.
STp is one of the main pathogens that cause piglets' diarrhea because of the metabolites secreted by E. coli, a pig-sourced enterotoxin, which is planted in the intestines. Using an in-body 3D culture model of pig intestinal stem cells created by the team, the study found that STp inhibited the Wnt/β-catenin signaling path, induced small intestine stem cells to develop into cystic organs, hindered the proliferation and differentiation of epithelial cells, promoted their apoptosis, and ultimately led to the destruction of the functional integrity of the intestinal mucosa structure and barrier.
The study for the first time analyzed STp through the targeting of Wnt/β-catenin signaling pathway, thereby changing the fate of intestinal stem cells, causing the mechanism of entero mucosal lesions, for the production of prevention and control of pig diarrhea provides a new way; (Source: China Science Journal Zhu Hanbin Chen Weichen)
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