The Ministry of Life Sciences issued a guide to guide the original exploration plan project guide

Announcement on the issuance of the guidelines for the 2021 guidance-oriented original exploration plan project of the Ministry of Life Sciences

Announcement on the issuance of the guidelines for the 2021 guidance-guided original exploration plan project of the Ministry of Life Sciences

National Natural Science Foundation Committee will now publish Life Sciences 2021 annual guide walks like the original exploration project guidelines, the applicant and the supporting institution in accordance with the requirements of the project guidelines and precautions apply
.

Committee member

Attachment: Guide to the “Future Biotechnology” Project Guide of the Guide-guided Original Exploration Project

Appendix

Appendix

Guide-guided original exploration plan project "Future Biotechnology" project guide

Guide-guided original exploration plan project "Future Biotechnology" project guide

The advancement of research in the field of life sciences depends on the innovation of research techniques and methods
.

Today, life science research is undergoing a research paradigm shift.

Committee member

1.
Scientific goals

1.
Scientific goals

Improve the current situation of insufficient original innovation capabilities in the field of biotechnology in China, actively promote the iterative update of biotechnology, break through bottlenecks in biotechnology applications and other links, develop technologies and methods for life body reading, transformation, synthesis, bionics, and regeneration, and broaden biology Technology application scenarios, promote multi-disciplinary cross-industry integration, promote the transformation of life science research paradigm, and provide theoretical reserves and technical support for the strategic tasks of serving the "four aspects" of basic research
.

2.
Research direction to be funded

2.
Research direction to be funded

Focusing on the above-mentioned scientific goals, it is planned to carry out relevant research in the following directions:

1.
biological phenomena observed in high-precision, multi-dimensional degree, cross-scale new principles, new methods and new technology research

1.
high-precision observation of the phenomenon of life, multi-dimensional degree, cross-scale new principles, new methods and new technology research multidimensional

Through new research paradigms and technologies, focusing on the technical principles of analyzing life phenomena and improving the accuracy, dimensionality, and scale of life process observations, break through the bottleneck of imaging, sequencing and other measurement technologies
.

Funding directions include, but are not limited to: breaking the current limit of temporal and spatial resolution of biological imaging, integration of multiple imaging modalities, label-free biological imaging, cross-scale imaging modal fusion, spatial multidimensional omics, single cell multidimensional omics, subcellular structure multidimensional genomics, chromatin multidimensional regulatory genomics, single molecule imaging, super-resolution imaging of living cells, in situ analysis or the like structure of biological macromolecules

Multi-dimensional multi-dimensional multi-dimensional multi-dimensional

2.
Technical principles and new methods of editing, design and manipulation of biomolecules

2.
Technical principles and new methods of editing, design and manipulation of biomolecules

Research and develop new technologies and methods that can achieve precise editing, design, and manipulation of biomolecules, including direct manipulation of various types of biomolecules, and conduct in-depth research on their technical principles, and strive to achieve breakthroughs in the development of new technologies
.

Funding directions include, but are not limited to: new programs and applications for editing and manipulation of DNA and RNA, design, synthesis and manipulation techniques of proteins, polysaccharides and lipids, design, construction and applications

3.
Principle exploration and technology development of labeling, tracing and regulation of the material flow and information flow of living organisms

3.
Principle exploration and technology development of labeling, tracing and regulation of the material flow and information flow of living organisms

Research and develop new technologies that can mark, trace, analyze and regulate the material flow and information flow in the living body, and conduct in-depth research on its technical principles
.

Including but not limited to the direction of funding: biologically active molecule, high integration and multi-specific probes efficient delivery techniques and in vivo tracer technique, tissue, structure and function of the simulated organ, repair and regeneration technology

4.
New technologies and new methods for rational design and engineering construction of artificial life systems

4.
New technologies and new methods for rational design and engineering construction of artificial life systems

Focusing on major scientific problems such as the essence of life and the origin of life, as well as major national needs such as medicine, chemical industry, food, and environmental protection, focus on original research on the rational (predictable) design, synthesis and creation of artificial biological systems, and strive to discover and develop new Theories, new strategies, new technologies and new methods
.

Funding directions include but are not limited to: rational design and synthetic reconstruction of artificial biological systems such as cell-free and hybrid life, rational design and synthetic reconstruction of organelles, cells, and multicellular systems, immune system reconstruction, correction and reconstruction technology, carbon dioxide efficient biological fixation of the biotransformation technology

5.
Quantitative analysis and calculation technology of life data

5.
Quantitative analysis and calculation technology of life data

For the accumulation of multidimensional large degree of biological data, research and development of new methods of data processing and analysis, realization of the project have their own copyright system, the new model can provide experimental verification of the new mechanism
.

Funding interests include but are not limited to: multi-dimensional specifications collect and share safety technology of cross-scale biological data, bio-computing technology and storage of digital information for biological computing hardware R & D expertise, precise Brain and Cognitive Sciences related to big data annotation, quantitative processing, computational analysis and modeling simulation, intelligent class brain research, artificial intelligence and new technology depth applications in the life sciences and so on

Multidimensional Multidimensional

6.
Development of new technologies for monitoring of trace substances and improvement of biological properties in the fields of agriculture and environmental ecology

6.
Development of new technologies for monitoring of trace substances and improvement of biological properties in the fields of agriculture and environmental ecology

New technology for monitoring high-sensitivity, high-throughput trace substances in objects and environments for graduate students, and new gene transformation technology for improving biological characteristics
.

Funding directions include but are not limited to: new technologies for high-throughput rapid monitoring of trace active substances such as hormones, environmental small molecule substances, new technologies for high-efficiency crop gene transformation or trait improvement, and technologies for carbon sink enhancement and maintenance

7.
Other future biotechnologies

7.
Other future biotechnologies

Technology research and development and tool development for solving major scientific problems in the field of life sciences and responding to specific life science research needs
.

3.
The funding period and funding intensity

3.
The funding period and funding intensity

The funding period for this original project is 1-3 years, and the funding intensity does not exceed 1 million yuan per project per year
.

Applicants can choose the funding period and propose funding requirements based on the actual needs of the research work

4.
Application requirements and matters needing attention

4.
Application requirements and matters needing attention

(1) Eligibility for application

Scientific and technical personnel who have undertaken basic research projects (projects) or other basic research experiences can apply
.
The research work that the applicant intends to carry out must meet the relevant regulatory requirements of the national biosafety conditions
.

(2) Provisions on application for restricted items

1.
Applicants can only apply for 1 original project (including pre-application) in the same year
.

2.
The original project application and review process will not be included in the scope of the total number of applications and undertaking projects, and will be included in the scope of the total number of applications and undertaking projects after being funded (except for projects with a funding period of 1 year or less)
.

(3) Application notes

1.
The application submission time is 16:00, November 1st-November 5th, 2021
.

2.
The applicant should choose one of the research directions published in this guide to apply, and the body of the application should clearly state which research direction in the guide this application belongs to
.
The "original project" special project guided by this guide is not only a paper, but the promotion and contribution of the project to the field should be clearly stated in the text
.

3.
This original project application is written and submitted online
.
Specific requirements are as follows:

(1) Applicants should carefully read this guide and the relevant content of the "2021 National Natural Science Foundation Project Guide" before filling in the application form.
Application projects that do not meet the project guide and related requirements will not be accepted
.

(2) Applicants are requested to log in to the National Natural Science Foundation of China Network Information System (hereinafter referred to as the information system) https://isisn.
nsfc.
gov.
cn, and fill in the application in accordance with the requirements of "Special Projects-Original Exploration Project Formal Application Form Writing Outline" Book
.
Applicants who do not have an information system account should apply to the contact person of the fund management of the supporting unit to open an account
.

(3) For the funding category in the application form, select “special project”, sub-category description select “guidance-guided original exploration plan project”, note description select “future biotechnology”, application code 1 select C21, application code 2 is based on project research The field involved chooses the corresponding subject application code
.
Applications for projects with inaccurate or unselected selections above will not be funded
.

(4) The total number of cooperative research units of the original project shall not exceed 2; the main participants must be actual contributors to the project
.

(5) Applicants should carefully read the content of the budget preparation requirements in the "2021 National Natural Science Foundation Project Guide" application regulations, carefully and truthfully prepare the project budget, and the supporting unit should carefully review it in accordance with the relevant regulations
.

(6) This original project adopts paperless application.
After the applicant completes the application form, submit the electronic application form and attached materials online
.
Relying units only need to confirm the electronic application and attached materials online, and do not need to submit paper applications, but the authenticity and completeness of the application materials submitted by the applicants of the unit should be carefully reviewed, and the information should be passed before the deadline for project application acceptance The system confirms the submission of the unit’s electronic application and attachment materials one by one; submits the list of the unit’s application items online within 24 hours after the deadline
.
After the project is approved, the supporting unit will bind the paper signature and seal page of the application to the end of the "Project Funding Plan" and submit it together as required within the specified time
.

(7) There is no review process for original project application and funding
.

(8) The original project consultation method:

Division of Cross-Convergence Science, Department of Life Sciences, Natural Science Foundation of China

Contact: Li Shuo

Contact number: 010-62329246

National Natural Science Fund Committee will

Committee member

Life Science Department

September 30, 2021