The molecular mechanism of HIV escaping from the host cell's defense system protects Chinese teenagers from HIV.

A team of researchers at Yokohama City University in Japan has discovered the molecular mechanism by which the human immunodeficiency virus (HIV), which causes AIDS, escapes from the host cell's defense system, the university has announced.
research was published in the recent online edition of Nature Communications.
HIV invades the human body, immune cells are gradually destroyed, the body is vulnerable to pathogens and cause a variety of diseases.
there is no cure for HIV completely excluded from the body, and infected people need to continue to take antiviral drugs for treatment.
with genetic mutations in the virus, there have been reports of many drug-resistant viruses that are not treatable by existing drugs.
therefore developing hiv vaccines at a time when new drugs against drug-resistant viruses need to be studied continuously.
human cells have the corresponding defense against various viruses.
, for example, the SAMHD1 protein is an enzyme produced by human cells that strongly blocks HIV-infected macrophages and CD4-T cells.
on the other hand, the virus, especially in West Africa, many infected people carry HIV-2, its particles contain Vpx protein can break down the cells samHD1, resulting in HIV-2 infection of bone marrow cells and T cells.
Because most viral proteins work with the help of human cell "viral regulators," the team first looked for factors that control vpx's effect on SAMHD1.
they searched for vpx-interactive proteins from more than 400 host proteins involved in phosphorylation modification and found that PIM kinase host proteins bind well to Vpx and were specifically phosphorylation.
detailed investigations with mass spectrometers show that serine is the 13th amino acid of Vpx and is phosphorylation by PIM kinase.
replace the serine with another amino acid, it will not produce vpx phosphorylation, and the proliferation of the virus will be significantly reduced.
research results show that the host PIM kinase is the regulatory factor that controls the effect of Vpx on SAMHD1.
, the study also found that by blocking PIM kinase, it can effectively block HIV-2 replication.
protecting Chinese teenagers from HIV Guangzhou is one of china's cities with serious AIDS impact, with an average annual increase of 46% in the number of cases reported among young students.
as part of the national HIV prevention and control strategy, the Chinese government is strengthening the strength of community organizations to help people with related needs to prevent the spread of HIV.
therefore, UNICEF is working with community organizations such as Lingnan Partners to encourage young people to receive government-provided testing and treatment services in a youth-friendly model.
22-year-old Xiaotian (pseudonym) received testing services at the Lingnan Partners clinic and trained as a consultant.
"Before i test visitors, I'll show you how to avoid high-risk behaviors and how to protect my information."
If the results are positive at the back, we will provide a consultant who will accompany you throughout the process to assist and assist with the referral to the hospital.
"-Lingnan Partners" also provideinformation and assistance to youth groups through the training of fellow educators of university students.
with the strong support of the local health and education system, Lingnan Partners works with student groups to teach students about safe sex and to introduce them to medical facilities for help when needed.
build trust, serving community children, many rural families living in difficult circumstances do not have access to them, despite the fact that China has established a welfare system designed to help the needy.
in rural China, many people have never heard of social work (social work) as a profession.
, it is not easy for those in the village to gain trust, especially in poor areas of the old and the young.
after attending a training organized by the China Public Welfare Research Institute of Beijing Normal University, Rui Ying, a children's director in Ruili County, Yunnan Province, began work in the village.
, who was driven out of the house with a broom by the child's mother while serving the first service object, is now a popular regular.
2010, UNICEF and the Ministry of Civil Affairs launched a pilot project on the construction of grass-roots child welfare and protection services.
eight years, the program has helped more and more children access social welfare, assistance and protection services.
2016, the State Council issued the Opinions on Strengthening the Protection of Children in Need, which called for the establishment of child welfare supervisors or child rights monitors in all village (residential) committees.
by the end of 2017, 127,000 village (residential) committees have been set up.
Source: Phoenix Network Integrated, Science and Technology Daily.