The molecular mechanism of plants to precisely regulate immune activity.

Like animals, plants have a natural immune system that reacts to various pathogenic microbial molecules through immune receptor proteins and transmits signals to other proteins in the cell.
immune response is strictly controlled and an efficient immune response ensures that plants and animals are resistant to pathogenic microorganisms, but over-immune responsecane lead to stunted plant growth and development and various human immune diseases.
therefore, it is important to accurately control the activity of the immune response.
, Zhou Jianmin, of the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences, worked with Zipfel of The Sainsbury's Laboratory in the United Kingdom and Jacqueline Monaghan Ofd.
the early work of Zhou Jianmin's research team, it is shown that cytoplasmic receptor kinase BIK1 is a hub protein that acts downstream of multiple immune receptors and controls multiple defense response pathways.
studies have shown that heterogenous G protein tripolymer and calcium-dependent kinase CPK28 regulate the accumulation of BIK1 protein in plants, respectively, but the mechanism of its regulation of the stability of BIK1 protein is not clear.
this new study, E3 ubiquitin connecting enzymes PUB25 and PUB26 promote salutation of the BIK1 protein through protease pathways, negatively regulating immune response and disease resistance.
the activity of PUB25/26 is regulated by the double regulation of G protein CPK28, while in the resting state, the G protein interacts directly with PUB25/26 to inhibit the activity of its ubiquitin-linked enzymes, thereby enhancing the stability of BIK1 and ensuring that the immune response can be initiated quickly when the disease is attacked, while in the immune activation state, CPK28 directly phosphorylated pubilythtic pu25/26, enhances its approxprox.25/26 activity to promote the hyperactivation of the immune activation.
researchers also found that PUB25/26 specifically targeted inactive forms of BIK1, and has no effect on the activated BIK1, which indicates that plants on the one hand by degradation of the unactivated BIK1, to avoid excessive accumulation of active BIK1, on the other hand to maintain the activated BIK1, the formation of immune balance, to ensure the immune response.
the results of the study, E3 ubiquitin connecting enzymes PUB25/26, G protein and CPK28 form an immune balance regulator, fine regulation of the stability of BIK1.
research published in Molecular Cell, with Dr. Jinlong Wang as the first author.
the research was funded by the National Natural Science Foundation of China, the Chinese Academy of Sciences strategic leading science and technology projects, and the National Key Laboratory of Plant Genomics.
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