The most complete summary: how much do you know about the four star indicators of inflammation markers?

*It is only for medical professionals to read for reference.
Have you mastered it? Being good at reviewing and summarizing is conducive to the formulation of new plans and new goals, as four star indicators of inflammation markers: C-reactive protein (CRP), serum amyloid A (SAA), procalcitonin (PCT), white blood cells How has interleukin-6 (IL-6) performed in recent years? Before the Spring Festival, come to take stock
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Number of registered products The number of CRPCRP registered products exceeds 500, the largest number, ranking first among the four major indicators
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Looking at the number of registrations in 2020 alone, the number of PCT registrations is slightly higher, and the number of SAA registrations is basically the same as the number of CRPs.
It is estimated that most manufacturers register together with CRP and SAA
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The smallest number of registrations is IL-6, but the number of registrations in 2020 alone accounts for half of the total number of registrations.
IL-6 is a rising star among the four inflammatory markers
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Table 1 (Note: Data from the China Food and Drug Administration as of December 10, 2020) The first place in the hospital's dosage CRPCRP is the earliest and most basic in clinical application, and the most dosage among the four indicators
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Next is SAA
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Because SAA can be combined with CRP and has unique advantages in the diagnosis of viral infectious diseases, it is suitable for assisting the diagnosis of infectious diseases in the outpatient and emergency department
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Table 2 looks at the status of registration and use of hospitals.
These indicators are widely used in clinical practice and have a larger market space
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Expert consensus/diagnostic path newly released the first PCT expert consensus/diagnostic path released in 2020.
The following 3 articles are more influential.
The first 2 mentions multiple testing items.
Only the PCT has a single expert consensus.
The PCT round wins
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The issuance of expert consensus has made the clinical use of these indicators more sufficient and more and more clinically recognized
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Table 3 Combination test Combination test: CRP+SAA for respiratory infections; PCT+IL-6 for neonatal sepsis
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In recent years, there have been many research articles on the four markers of inflammation.
Some studies simply mentioned that the combined application of four or three items of inflammation has higher diagnostic efficacy than a single item, but did not compare the diagnostic efficacy of a combination of two or three items
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From the perspective of health economics, it is rare for clinical practice to carry out 4 item combination tests at the same time.
It can also be seen in the analysis of two or three combinations that the diagnostic efficacy of many indicators of three or two combinations is comparable to the four items.
The combination is very close
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The following is a selection of several articles published in 2020 to compare and analyze the diagnostic value of different combinations of multiple items
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Table 4 In addition to the conventionally recommended combination of CRP+SAA for respiratory infections and the combination of PCT+IL-6 for neonatal sepsis, some new combined tests have higher diagnostic value, such as: 1.
Viral children's community The combination of SAA/PCT ratio of acquired pneumonia is better than the ratio of SAA/CRP and SAA/IL-6
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2.
The ratio of IL-6/PCT has a higher value in the diagnosis of Mycoplasma pneumoniae CAP
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3.
The SAA+IL-6 combination is more valuable in the diagnosis of intrauterine pneumonia in neonates than other combinations
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The combination of SAA+PCT and SAA+IL-6 has shown good application value in some studies, but the current research is relatively small, and more research and verification are needed.

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Each inflammation index has different characteristics and applications.
Have you mastered them all? At the end of the article