The new coronavirus is highly contagious, too much more contagious than SARS, why is the new coronavirus highly contagious?

Experts: the new crown virus is highly contagious, the late stage must not be paralysed" experts said that the late stage can not be paralysed to the effect that the eighth people's hospital in Guangzhou, Cai Weiping in the afternoon interview with China Daily, said that the new crown virus is highly contagious, than 17 years ago SARS infectious too much.
" the initial everyone's prevention is very tight, prevention and control above will not be a big problem.
but in the later stages, everyone's palsy mood came out, careless may be infected with the virus.
cannot say that early patients are highly contagious, and late-stage infectiousness is not strong.
feel this virus infection, do not know how many times stronger than SARS.
" Guangzhou Eighth People's Hospital is the year SARS fixed-point hospital, according to Director Cai Weiping, when medical staff wearing veil masks, infection cases are more than a dozen cases.
", "If you put it in today, just wear ingons and go in, people in the whole area could be infected."
", "China Daily" Why is the new crown virus highly contagious? All over the country after the Spring Festival to return to work mode has been opened, the new coronavirus infection pneumonia epidemic prevention and control situation is serious. How does
virus invade the human body? Why is the new crown virus contagious? Why is it difficult to develop antiviral drugs? What experience scored on the victory over SARS 17 years ago for reference in this war epidemic? Dr. Sun Yongchang, Standing Committee and Secretary-General of the Respiratory And Critical Care Department of the Chinese Medical Association's Respiratory And Critical Illness Espresso Association, was interviewed through the network to analyze the outbreak of xinguan pneumonia to the media.
the same mechanism of SARS infection human Sun Yongchang said that the virus through nonspecific Brown movement to the surface of the human respiratory tract cells, the virus surface of the virus binding protein and the body cell surface receptors irreversible specific identification and binding.
then, the virus enters the body's cells by drinking, fusing, or penetrating directly.
the virus enters the cell, it removes the protein shell and exposes the virus genome.
viral genomes are assembled into mature viruses using the nucleic acids and proteins of host cells to synthesize viral nucleic acids and viral structural proteins.
the final release of mature viruses in these cells, and some kinds of viruses destroy host cells during release.
release a large number of viruses and then enter the next susceptible host cell, so a vicious cycle that eventually leads to tissue and organ damage.
he points out that the SARS virus invades by binding to a receptor called angiotensin conversion enzyme 2 (ACE2) in human cells, and new research has found that the receptor of the new coronavirus is also ACE2, which is the primary target of the new coronavirus because of the high expression of ACE2 in human alveosphmy II cells.
also found that organs such as the heart, esophagus, kidneys and bladder all express ACE2, suggesting that these organs may also be affected by the new coronavirus.
the new crown virus transmission power is strong there are four reasons Sun Yongchang analysis that the new crown virus transmission power is strong, there are four main reasons: First, the incubation period of the new crown virus has the ability to spread, so it has a long time of infectious.
is that the clinical symptoms of new coronary pneumonia are atypical, and asymptomatic infections are also contagious.
third is the spread of the new coronavirus in a variety of ways, mainly through respiratory droplets, eyes, mouth or nose mucous membrane indirect contact, there is also the possibility of aerosol and feces-mouth transmission, although this aspect is still to be further confirmed, but should cause a high degree of vigilance.
fourth is that there are two regions in the coronavirus genome that are highly susceptible to mutations, namely, the gene regions that encode the sting protein and the auxiliary protein.
Because coronaviruses try to bind to new receptors to escape the immune response, coronaviruses produce many replication errors in these two gene regions, which promote the evolution of the virus and ultimately lead to the ability of the coronavirus to be transmitted from one species to another.
as to the new crown virus than SARS more cunning, Sun Yongchang believes that it is not the new crown virus is more cunning, but people know little about the new virus, the performance and law of its disease is not enough to understand.
at present, the new crown virus infection patients, typical have fever, cough, pneumonia, but there are also many patients do not have fever, no cough, not even obvious pneumonia.
antiviral drug action target is very difficult to develop and increase antiviral drug research and development why difficult? Sun Yongchang said that the virus must rely on living, cell-structured organisms, in order to carry out their own proliferation, and when given antiviral drugs, will have an lethal effect on host cells, therefore, antiviral drug research and development compared to antimicrobial drugs significantly higher than a difficulty level.
"The virus is always evolving, and nearly 20 years of clinical experience have taught us that any virus that comes with it is a completely new virus, and there is no way in the early days."
some viruses such as HIV, influenza A virus replication mutation rate is particularly high, prone to drug-resistant strains.
at the same time, drugs are in the process of virus replication as a target, do not copy the latent virus invalid, and antiviral drugs are very many targets, research and development difficulties increased, really implemented to a certain antiviral drug, there are very few choices.
therefore, drugs, especially antiviral drugs, research and development itself is a time-consuming, labor-intensive, money-consuming process, requiring huge economic and human investment.
he stressed that the difficulty of antiviral drug development does not mean that there is no cure for viral infection, there are now a variety of antiviral drugs can be through different mechanisms of action to suppress virus replication, effective treatment of virus-induced diseases.
currently, the drug for the new coronavirus has been stepped up screening and development, the high-profile Redsewe is conducting clinical trials.
in response to the outbreak of pneumonia with a new coronavirus infection, more than a dozen volunteers from the Changsha Blue Sky Rescue Team, armed with heavy disinfection machines, disinfected the inside and outside Changsha Railway Station.
China News Agency reporter Yang Huafeng to overcome SARS three experienceworthy reference Sun Yongchang said that China's victory over SARS 17 years ago, many experience, can be used for this war "epidemic" to learn from, the most important of which is three points: First, after SARS China set up a response to sudden, new respiratory infections system, system, which later in response to human infection with avian influenza, 2009 influenza epidemic, play an important role.
second is through SARS, medical personnel have the operational ability and psychological preparation to overcome new respiratory infections on the basis of effective protection.
third through SARS War I, realize the importance of respiratory discipline and critical medical bundled development, hospitals at all levels have set up and perfected the respiratory disease diagnosis and treatment and medical critical illness treatment ability of the discipline system - respiratory and critical medical department, cultivate a large number of medical personnel with corresponding capacity, but also become the new crown pneumonia war "epidemic" the main force.
Source: China News Network Sun Zifa 15 seconds contact on the infection shows that the new crown pneumonia is particularly contagious? Wang Guiqiang is the Director of The Infectious Diseases Department of Peking University First Hospital and the Director of the Chinese Medical Association's Infectious Diseases Committee.
during the outbreak of new crown pneumonia, he as a state-level medical expert, assigned by the National Health and Care Commission, to Anhui and other places to guide the treatment of critically ill patients, and to participate in the revision of the fifth edition of the new crown pneumonia diagnosis and treatment program, on behalf of the expert group to participate in the State Council joint prevention and control mechanism press conference.
15 seconds of exposure to the disease means that the new crown pneumonia is particularly contagious? Why do people with mild illness suddenly die of an aggravated illness? Why is the nucleic acid detection "false negative" phenomenon frequent? On these issues, Xinhua News Agency reporter february 10 interview with Director Wang Guiqiang, let's get to know it! Q: The recent 15-second exposure to the case that led to infection with the new coronavirus shows that the new crown pneumonia is particularly contagious? Wang Guiqiang: The virus is generally more contagious, 15 seconds of contact caused by transmission is entirely possible.
if there is no protection, the local virus is very high, not for how long, a word of work droplets may arrive, you are infected.
don't say 15 seconds, 2 seconds can also cause infection, so protection is important.
ask: What is aerosol propagation and what are the specific conditions? Wang Guiqiang: Image said, aerosol is equivalent to the sun, you see the room floating a small amount of dust, is that kind of feeling.
so aerosol transmission in respiratory infections, is an important way of transmission.
, however, aerosol transmission has specific conditions, not that there is aerosol where all spread.
the size of the environment is important, the density of the virus in the unit volume is decisive.
, for example, if the virus floats in the atmosphere, in the outdoor environment, the probability of infection is very low, so we emphasize that outdoors, on the street and other places generally do not cause infection.
if in a small environment, such as animal experiments to do culture laboratory space, including the current nucleic acid testing space, may form aerosolfloatfloatfloatfloats floating in the air, poor protection may cause transmission.
in a particular working environment, air circulation can also create a risk of transmission.
for example, the office is not ventilated, there are several people have worked inside, although this office is no longer used, no one, but there may still be aerosols, after entering the unprotected may be infected. such an environment as an elevator
is also high risk.
on such occasions, we are advised to do a good job of protection.
we've always recommended wearing a mask in a small, unventilated area, which in itself is a protective measure against aerosol transmission.
at present, this measure is effective against aerosol protection.
ask: Why are some patients in critical condition, some patients can self-healing at home? Wang Guiqiang: The same virus infection of patients, some are light, some are ordinary type, and some are heavy, which is closely related to the individual's immune state.
at present, the higher mortality rate of new coronary pneumonia patients are mainly the elderly and the two types of underlying diseases.
is due to poor resistance and poor immunity in the elderly, and patients with underlying diseases may become more severe during the infection of new coronary pneumonia.
for example, patients with chronic bronchitis combined viral infection, there will be secondary bacterial infection, the condition will easily worsen.
asked: Why do people with mild illness suddenly get sick and die? Wang Guiqiang: Immunity is a double-edged sword, the body's immune activation attempts to remove foreign pathogenic microorganisms, will lead to the body's own harm.
if the virus is large, immunity is very strong, there will be a more intense local struggle, resulting in local inflammation, cell damage, is the so-called inflammatory factor storm, this time the condition may worsen.
, therefore, sometimes the stronger the immunity, but the more serious the disease, the faster the progress.
we mentioned in the clinic that conditions can be tested for cytokines.
If there is a clear storm of inflammatory factors, a large number of inflammatory factorrelease, do not let it have a strong response, can use hormones, cglobulin and other drugs to solve the problem of inflammatory factor storms, or through blood purification, plasma replacement to reduce inflammatory factors.
an inflammatory response after infection is inevitable, this is a normal immune process, but too strong immune response to the body damage is greater, we hope to have some control, some inhibition.
: What is the significance of Wuhan's construction of a "square cabin hospital"? Wang Guiqiang: "Party cabin hospital" in the existing emergency state is a good means, mainly used to focus on the treatment of light confirmed cases.
these patients do not need to be systematically treated in large hospitals and general hospitals, saving beds for people at risk of becoming more serious, and further reducing the fatality rate, while also addressing the need for isolation and care in light and confirmed cases.
some light cases may be turned into ordinary or even heavy, in the "square cabin hospital" is conducive to these patients in a timely manner to identify, timely transfer, so it is also equivalent to a transit station.
the significance of the "square cabin hospital" at this stage is very large, and achieves the goal of isolating patients, identifying patients in a timely manner and diverting them.
ask: What should we do in the face of suspected cases? Wang Guiqiang: All suspected cases should be targeted medical institutions for isolation and treatment, diagnosis and treatment program is written so, I hope you must implement.
if not done, resulting in dissemination, is to be held accountable.
pay special attention to people from Hubei, as there is a real risk of transmission.
this is not discrimination, from the perspective of infectious disease control, this group of people to pay special attention to.
ask: Why is the nucleic acid detection "false negative" phenomenon frequent? Wang Guiqiang: The first factor is the sensitivity of the detection technology, which is the detection technology itself.
is the specificity of detection means, sensitivity is not good enough;
, so, in the fifth version of the diagnosis and treatment plan, we recommend changing to a nasopharyngeal swab, originally just said the pharynx swab.
at present, from the respiratory infectious diseases, the nasopharyngeal swab test positive rate is higher, including a stream of alike, B-flow, are mainly to nasopharyngeal swab testing. The second factor
is the disease itself.
xinguanpneumonia is an infectious respiratory disease, the virus is mostly through the respiratory tract into the body, so the upper respiratory tract of the virus may be relatively large.
the disease progresses to a certain extent, mainly infected the lungs, a large number of viruses in the lungs to reproduce and release, leading to inflammation of the lungs.
at this time the upper respiratory tract virus may be less, because the respiratory mucosa itself has a certain immune state, natural immunity plays a role, the upper respiratory tract test may be negative.
at this time the lower respiratory tract sample test, the positive rate must be high.
, however, just get sick, the lower respiratory tract may not be able to detect, to wait for pneumonia, cough and sputum, its positive rate must be high.
this is determined by the nature of the disease itself.
ask: What are the practical needs of the grass-roots level in the diagnosis and treatment technology? Wang Guiqiang: Now the diagnosis of nucleic acid is widely used, the kit is in sufficient supply.
at the grass-roots level, objectively speaking, PCR polymerase chain reaction technology still has a bottleneck.
it requires a PCR lab and a certain level of protection.
therefore, at the grass-roots level, it may be difficult to carry out.
some patients at the grass-roots level, can not carry out effective nucleic acid screening, may affect the diagnosis and treatment of the disease.
is easy to do.