echemi logo
  • Product
  • Supplier
  • Inquiry
    Home > Biochemistry News > Biotechnology News > The new coronavirus S protein directly binds and activates TLR4 to induce anti-bacterial innate immune response

    The new coronavirus S protein directly binds and activates TLR4 to induce anti-bacterial innate immune response

    • Last Update: 2021-08-11
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit

    Recently, the You Fuping research group of the Institute of Systems Biomedicine of Peking University and the Wang Xiangxi research group of the Institute of Biophysics of the Chinese Academy of Sciences have published a research paper entitled "SARS-CoV-2 spike protein interacts with and activates TLR4" in Cell Research

    The team purified the trimeric crown protein (1-1208aa) in vitro using 293 cells for research

    The researchers also successfully inhibited the effects of the coronavirus on the above-mentioned cell experiments by using inhibitors of key molecules of the TLR4 pathway (including TLR4 inhibitor Resatovir, CD14 antibody blockade, MD2 inhibitor T5342126, and NF-κB inhibitor JSH-23).

    Researcher You Fuping, Institute of Systems Biomedicine, Peking University School of Basic Medicine, and Researcher Wang Xiangxi, Institute of Biophysics, Chinese Academy of Sciences, are the co-corresponding authors

    Original link: https://

    This article is an English version of an article which is originally in the Chinese language on and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to with relevant evidence.