The New England Journal of Medicine published the results of original stroke clinical research at the First Affiliated Hospital of China University of Science and Technology

Endovascular thrombectomy within 12 hours in patients with acute basilar artery occlusion is superior to optimal medical therapy

Opening the blocked blood vessels as soon as possible after ischemic stroke is the key to treatment and prognosis, and the most effective treatment for acute ischemic stroke is venous thrombolysis and arterial thrombectomy
。 Initiated by Hu Wei, chief physician of the Department of Neurology, The First Affiliated Hospital of the University of Science and Technology of China (Anhui Provincial Hospital), and Professor Liu Xinfeng, vice president of the First Affiliated Hospital of the University of Science and Technology of China (Anhui Provincial Hospital) and professor Liu Xinfeng, General Hospital of the Eastern Theater, the results of a prospective, multicenter, randomized controlled study on the efficacy and safety of arterial embolectomy in the treatment of acute basilar artery occlusion proved that patients with acute basilar artery occlusion can benefit from arterial embolectomy within 12 hours of onset.
Compared with the best medical treatment, arterial embolectomy can significantly improve patients' ability to live independently and reduce mortality
.

In the early morning of October 13, Beijing time, the New England Journal of Medicine, a top international medical academic journal, released relevant research results
.
This is the first successful clinical randomized controlled study (RCT) on the efficacy and safety of acute basilar artery occlusion of arterial embrombectomy and has been internationally recognized
.

On the morning of October 13, the First Affiliated Hospital of China University of Science and Technology held an online press conference
on the clinical research results of ATTENTION stroke, "New England Journal of Medicine".
Zhu Jiping, Executive Deputy Director of the Propaganda Department and Director of the News Center of the Party Committee of the University of Science and Technology of China, Professor Liu Lianxin, Secretary of the Party Committee and Liu Jun, Deputy Secretary of the Party Committee of the First Affiliated Academy of the University of Science and Technology of China, representatives of the ATTENTION research team, and responsible comrades of the Propaganda and United Front Work Department of the Party Committee of the Academy attended the meeting
.
The press conference was held
in strict compliance with the current epidemic prevention and control requirements.

Liu Jun, deputy secretary of the party committee, released the ATTENTION research results, and Professor Hu Wei, one of the project leaders and chief physician of the Department of Neurology of the First Affiliated Hospital of China University of Science and Technology, answered reporters' questions
on the research results.
More than 10 national, provincial and municipal mainstream news media, including Xinhua News Agency, China Central Radio and Television Station, China News Service, China Youth Daily, People's Daily News, China Science News, and Health News, attended the
press conference.

Foreign experts involved in the study, Professor Qureshi Qureshi of the University of Missouri Stroke Center, and Professor Nogueira Nogueira of the Department of Neurology and Neurosurgery of the University of Pittsburgh School of Medicine in the United States sent congratulatory videos

Stroke, commonly known as "stroke", is the "number one killer" endangering life and health, in China, at least 1 in every 5 deaths die of stroke
.
According to the latest China Stroke Report 2020, at present, the number of new strokes in China is about 3.
94 million every year, and the death toll has reached 2.
19 million, which has caused a heavy burden
to the country, society and families.

Among all types of stroke, posterior circulation stroke accounts for about one-fifth, of which posterior circulation infarction caused by acute basilar artery occlusion tends to have a worse prognosis than anterior circulation large vessel occlusion, and the mortality and disability rates of patients are higher
.
However, due to the lack of high-quality, evidence-based medical evidence, the effectiveness and safety of arterial thrombectomy in patients with stroke due to acute basilar artery occlusion remains unclear
in the international medical community.
The ATTENTION study demonstrated with high-quality, evidence-based medical evidence that patients in the arterial thrombectomy group had a significantly better prognosis than the best medical treatment group
for acute basilar artery occlusion.

A total of 340 patients from 36 medical centers in 31 cities in 13 provinces and 13 provinces were randomly assigned to arterial embolectomy + drug treatment group and the best drug treatment group according to the ratio of 2:1, and 226 people and 114 people in the final thrombectomy treatment group and control group were included in the analysis
.
The mean age of the study population was 66.
5 years, the median baseline NIHSS score (neurological deficit score) was 24 points, the median time to onset to randomization was about 5 hours, and 31% and 34% of patients in the arterial thrombectomy and control groups, respectively
, received intravenous thrombolysis.

On November 27, 2020, the first seminar of the ATTENTION project research program was held in Hefei

The results of the ATTENTION study demonstrated that the proportion of patients in the acute basilar artery occlusion embolectomy group who achieved a better neurological prognosis within 90 days was significantly better than that in the best drug treatment group
, referring to the modified Rankin scale (mRS), which measures the neurological recovery of patients after stroke.
There was also a significant advantage in the thrombectomy group across all secondary outcomes, with the proportion of patients in the embolectomy group having the ability to live independently within 90 days significantly better than the control group, and the benefit ratio was comparable to that of anterior circulation endovascular therapy compared with optimal medical therapy
.
In addition, the embolectomy group showed a lower risk
of death within 90 days.

Founded for more than 200 years, the New England Journal of Medicine provides important, unpublished research, clinical findings, and perspectives, focusing on the usefulness of articles, with a latest impact factor (IF) of 176.
079 in 2022, making it one of
the most widely read, cited and influential comprehensive medical journals in the world.

With Chinese data, ATTENTION answers the worldwide stroke problem of the best treatment of acute basilar artery occlusion, which provides important enlightenment for the future research direction of acute basilar artery occlusion, and is of great significance
to stroke prevention and treatment in China and even the world.

The First Affiliated Hospital of China University of Science and Technology is the only "National Model Advanced Stroke Center" and "China Stroke Center Training Base" in Anhui Province, with a smooth stroke emergency green channel and an excellent stroke treatment team, thrombolysis and thrombectomy teams are on standby 24 hours a day all year round, doing their best to treat acute stroke patients
.
(Department of Neurology, Tao Chunrong, Sun Jun/Wen Propaganda and United Front Work Department of the Party Committee of the First Affiliated Academy, Huang Xin, Department of Neurology, Sun Jun/Figure Wang Guoping, Yin Dalong/Review)

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