The new gene of low oxygen adaptation has important potential functions in solid tumors
Last Update: 2021-02-28
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Reporter November 3 from the
Kunming Institute of Zoology was informed that the institute's researchers have recently revealed in the development of low oxygen adaptation and non-small cell lung cancer, an amplified protein important functions and molecular regulatory mechanisms. The latest research was published online in the international authoritative journal Nature Communications.
The Chen Yongbin discipline group of Kunming Animal Research Institute, which is engaged in tumor signal transduction research, and Wu Dongdong, who is engaged in primate evolutionary genetics and development research, used evolutionary biology methods to screen a series of key new molecules of hypoxia adaptation from large-scale population genomes and transcription group data of Tibetan mammals, including dogs, horses, cattle, sheep, etc., and found that many reported tumor star genes were positively selected in highland mammals. In addition, they found that in high-altitude areas such as Tibet, age-standardized mortality rates for various human cancers, such as lung, colorectal, liver and breast cancer, were significantly lower than in other provinces, which also meant that the new hypoxic adaptation gene had potentially important functions in low-oxygen solid tumors. Dr. Shi Yulin, a member of the
Chen Yongbin discipline group, said they found that YTHDF1, as a member of the m6A modified RNA binding protein family, had low expression in highland-based mammals, while inhibiting its expression in normal pulmonary endosperm cells was resistant to hypoxic-induced apoptosis. In-depth research has found that YTHDF1 is highly expressed in tumor tissue and cell line of non-small cell lung cancer, and promotes the proliferation of tumor cells by accelerating the expression of several cell cycle proteins under normal oxygen conditions, while in the platinum drug-based chemotherapy pressure environment, the high expression of YTHDF1 makes tumor patients more sensitive to chemotherapy and has a longer total survival time.
This study shows that using the non-patterned animal genomes of the
environment to screen the genes associated with hypoxia adaptation through evolutionary biology methods can provide new research methods for the excavation of new biomarkers of hypoxic solid tumors, which also indicates that interdisciplinary disciplines have important application prospects in the field of medical biology in the future. This study not only provides new insights into adaptive evolution, but also provides direction for finding therapeutic targets for cancer. They also advocate the use of evolutionary methods and conceptual requirements to understand the progression and characteristics of cancer from different perspectives.
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