The paper summarizes the processing and functional mechanism of ring RNA generation.

On July 26, Chen Lingling Of the Institute of Biochemistry and Cell Biology of the Chinese Academy of Sciences and Yang Li Ofi Ofaulogy Of the Institute of Computational Biology of the Chinese Academy of Sciences-Map Society were invited to publish a review paper on The Biogenesis, functions and challenges of the circular RNAs in Molecular Cell. The ring RNA of the
the source of the exoon reverse splicing is a new RNA molecule that does not have a 5' end hat and 3'end poly(A) tail, but forms a closed-loop structure at a common price key, and is mainly produced by precursor RNA RNA from the reverse shear produced by RNA polymerase II transcription.
in recent years, with the development and application of new technologies for transcription sequencing, and the continuous optimization of corresponding computational biological analysis processes, scientists have found hundreds of thousands of exons in eyreum slicing ring RNAs in eukaryotic organisms.
Chen Lingling's research team recently published in Molecular Cell on this ring RNA-related special review paper, the ring RNA generation processing, functional mechanisms, etc. made a systematic summary and combing. the generation and processing of the transnocinite reverse splicing ring RNA
is strictly regulated and occurs at several levels, including transcription speed, transcription of multi-reverse transgene site, composition of the shear complex, conforming action element, and/or trans-agent regulation.
more importantly, despite the lack of clarity about the function of most ring RNA, a growing body of research has revealed that some ring RNA can be involved in cell or individual normal life activities through different molecular mechanisms, including nano-RNA and protein molecular sponges, affecting RNA transcription, interfering with the normal shearing of RNA precursors, and even the generation of peptides through translation.
However, since linear mRNAs almost completely cover the base sequence of ring RNA of the same gene source, it is difficult to study the expression and function of ring RNA specifically without affecting linear mRNA expression.
overcome bottlenecks and challenges in ring RNA research technology and develop new tools for specific targeted ring RNA, which will better facilitate the study of ring RNA generation and functional regulation. Li Ling, a ph.d. student at the
Chen Lingling Research Group, is the first author of the thesis, and Chen Lingling and Yang Li are co-authors.
related work has been supported by the Chinese Academy of Sciences, the National Natural Science Foundation, the Ministry of Science and Technology, HHMI International Project, etc.
.