The pattern of ploidal changes in early embryonic development in primates has been revealed

The team of Zheng Ping of Kunming Animal Institute of the Chinese Academy of Sciences and Han Jingdong of the Institute of Computational Biology of the Shanghai Institute of Life Sciences of the Chinese Academy of Sciences found that the fate decision pattern and regulation of early embryonic cells in macaques are very similar to those of human embryos, revealing for the first time that there is a process of transition of developmental ploid from primitive state to origin in primate bed-front embryos. The results were recently published
. Developmental plocyticity refers to the potential of one cell to differentiate into other cell types. In the early embryonic development process, the plocyticity of embryonic cells decreases gradually with the development. Plive state can be divided into primitive plive state and originating plive state with different degree of development. The original plive state has stronger mosaic formation ability and development potential than the original multi-energy state. The upper embryo cells in front of the bed of rodents are in the original erypotent state, which is converted to the originating multi-energy state after the bed, so it is easy to establish a primitive popotent embryonic stem cell line from the bed front embryo. In primates, however, the pattern of changes in the errative state of early embryos is not clear.
The researchers collected information on the dynamic changes in the development of macaque blastocysts over four periods (early blastocyst, mid-stage blastocyst, late blastocyst, incubation blastocyst) and upper embryo cell plocytes, and found that primates have different states of developmental ploids in pre-bed embryonic cells. In the early and middle blastocyst period, the upper embryo cells were in the original multi-energy state, after which the original multi-energy characteristics were lost, and the originating multi-energy characteristics were gradually obtained. Therefore, unlike rodents, the time window for the primate's original erythic state to exist is extremely short. The study explains why primate primitive erythral embryonic stem cells are difficult to obtain and provides a time window for how to build primitive posynthon popotent stem cells from the blastocyst. (Source: Jin Nan, China Science Daily)