The physical factors affect the development of stem cell collection

) -- Scientists have discovered the mystery of how factors influence the development of embryonic stem cells, stemming from a uniquely shaped cellular structure. Scholars from Tsinghua University, Beijing University of Aeronautics and Astronautics and Harvard University recently pointed out in the journal Cell-System that the surface pressure of mouse embryonic stem cell colonization evolves with the process of proliferation and differentiation, and its surface pressure comes from the contraction of the three-dimensional supercellular myoglobulin cortical layer.
the process by which cells feel the micro-environment of cytomethics is actually the process by which cells convert the sensory stimuli into biochemical signals, called cytological signal conduction. Du Wei, the first author of the paper, told the China Science Journal that most of the endotrate cells cultured on the flat plate are single-layer growth, poor three-dimensional sense, a spontaneous formation of a very three-dimensional structure of stem cell collection has attracted the attention of the research team.
stem cell clusters spontaneously maintain their unique shape? The answer may be mechanical mechanics. By using an atomic force microscope to detect the evolution of the elastic mod of stem cell collection, and using a micro-laser cutting method to examine the surface tension of the collection, the team found that the tension on the surface of the embryonic stem cell collection in mice gradually decreased as the stem cells grew and differentiated. The microscopic skeletons on the collecting surface are an important cause of the formation of stress, and these microscopic skeletons produce contractions under the effect of myoglobin, thus exerting pressure on the cells inside the collection.
study further found that internal pressure in mouse embryonic stem cell collection promotes the expression of two genes, Nanog and Oct4, which also have a positive effect on blastocyst development in the supercellular 3D myoglobulin cortical layer.
"there has been less research focusing on the effects of genetic factors on embryonic stem cells." In addition to the effects of gene regulation and biochemical signals, our study also introduces mechanical factors into it. Du said that in the future, the task force will continue to explore the internal mechanism of surface stress changes.
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