The principle of peptide synthesis
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Last Update: 2020-11-01
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Source: Internet
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Author: User
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the theory of synthesis is mainly to arrange
amino acids
in a certain order, using amino and carboxyl dehydration to form peptide bonds, and thus form the structure we need.
in order to avoid side reactions, we need to protect unreactable aminos in advance so that they do not participate in the synthesis process, thus avoiding the generation of by-products. Otherwise, the general radon-based activation method increases the reaction activity, which is always accompanied by a decrease in reaction selectivity, on the other hand, although the selectiveness is improved, the reaction activity is not enough.
, the fundamental problem of peptide synthesis is the protection of amino. Synthetic
peptides
by solution phase and solid phase methods. Solid-phase synthesis has advantages over liquid-phase synthesis, and both methods have some advantages and disadvantages.
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