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    Home > Active Ingredient News > Antitumor Therapy > The Production Process of 1,4-BIS[3,4-DIHYDRO-2(1H)-QUINOLINON-7-OXY]BUTANE

    The Production Process of 1,4-BIS[3,4-DIHYDRO-2(1H)-QUINOLINON-7-OXY]BUTANE

    • Last Update: 2023-05-12
    • Source: Internet
    • Author: User
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    The production process of 1,4-BIS[3,4-dihydro-2(1H)-quinollinon-7-oxy]butane, also known as CX-704, involves several steps that must be carried out in a precise and controlled manner to ensure the production of a high-quality product.

    1. Synthesis of 1,4-BIS[3,4-dihydro-2(1H)-quinollinon-7-oxy]-2-butanone
      The first step in the production process of CX-704 is the synthesis of its precursor, 1,4-BIS[3,4-dihydro-2(1H)-quinollinon-7-oxy]-2-butanone.
      This compound is synthesized by reacting 3,4-dihydro-2H-quinol-2-one with 2-butanone in the presence of a strong acid catalyst, such as sulfuric acid.
      The reaction is carried out in a well-ventilated room and the temperature is maintained at around 80-90°C.
    2. Reduction of 1,4-BIS[3,4-dihydro-2(1H)-quinollinon-7-oxy]-2-butanone
      After the synthesis of 1,4-BIS[3,4-dihydro-2(1H)-quinollinon-7-oxy]-2-butanone, the next step is to reduce the molecule to produce 1,4-BIS[3,4-dihydro-2(1H)-quinollinon-7-oxy]butane.
      This reduction reaction is carried out by hydrogenation in the presence of a catalyst, such as palladium on barium sulfate.
      The reaction is carried out at a temperature of about 50-60°C and a pressure of about 50-60 psi.
    3. Purification of 1,4-BIS[3,4-dihydro-2(1H)-quinollinon-7-oxy]butane
      After the reduction reaction, the product is purified to remove any impurities that may have been introduced during the synthesis and hydrogenation steps.
      This purification step typically involves recrystallization, which involves dissolving the product in a solvent, such as ethanol, and allowing the crystals to form through slow evaporation.
      The crystals are then collected and dried to remove any remaining impurities.
    4. Characterization of CX-704
      To ensure the quality and purity of the final product, it is important to characterize CX-704 using various analytical techniques.
      These techniques may include spectroscopic methods, such as infrared spectroscopy and nuclear magnetic resonance spectroscopy, and chromatographic methods, such as high-performance liquid chromatography.
    5. Formulation and Packaging of CX-704
      After the product has been purified and characterized, it is ready to be formulated and packaged for commercial use.
      This typically involves mixing the product with other ingredients, such as excipients and stabilizers, to create a stable and effective formulation.
      The final product is then packaged in containers that are suitable for storage and transportation.

    In conclusion, the production process of 1,4-BIS[3,4-dihydro-2(1H)-quinollinon-7-oxy]butane involves several steps that must be carried out in a precise and controlled manner to ensure the production of a high-quality product.
    This article has provided a brief overview of the key steps involved in the production process, from the synthesis of the precursor molecule to the purification and characterization of the final product.
    Understanding the production process is important for ensuring the quality and efficacy of CX-704 and for developing new and improved formulations of this compound.

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