The Production Process of 2-Amino-5-isopropyl-thiophene-3-carboxylic acid ethyl ester ,97%

The production process of 2-amino-5-isopropyl-thiophene-3-carboxylic acid ethyl ester, a derivative of thiophene, is a multi-step process that involves several chemical reactions and purification steps.
The starting materials used in the production of this chemical are 2-amino-5-isopropyl-thiophene-3-carboxylic acid and ethyl alcohol.
The final product is a white or slightly yellowish solid with a melting point of around 210-215°C.

The first step in the production process is the synthesis of 2-amino-5-isopropyl-thiophene-3-carboxylic acid, which is synthesized by reacting isopropylamine with 3-bromothiophene-2-carboxylic acid in the presence of a Lewis acid catalyst, such as aluminum chloride.
The reaction is typically carried out in a polar solvent, such as THF, at a temperature of around 0°C to 10°C.

Once the 2-amino-5-isopropyl-thiophene-3-carboxylic acid is synthesized, it is then esterified with ethyl alcohol to produce 2-amino-5-isopropyl-thiophene-3-carboxylic acid ethyl ester.
This esterification reaction is typically carried out in the presence of a catalyst, such as sulfuric acid, and is typically performed at a temperature of around 100°C to 110°C.

After the esterification reaction is complete, the reaction mixture is typically filtered to remove any solid impurities and the filtrate is then concentrated to remove excess ethyl alcohol.
The resulting concentrate is then purified by recrystallization, which involves dissolving the concentrate in a suitable solvent, such as ethyl acetate, and then allowing the mixture to slowly cool and crystallize.
The crystals are then collected and dried to remove any remaining solvent.

The purified 2-amino-5-isopropyl-thiophene-3-carboxylic acid ethyl ester is then typically characterized by spectroscopic methods, such as NMR and mass spectrometry, to confirm its structure and purity.
The final product is a white or slightly yellowish solid with a melting point of around 210-215°C.

In summary, the production process of 2-amino-5-isopropyl-thiophene-3-carboxylic acid ethyl ester, 97% involves several chemical reactions and purification steps.
The process starts with the synthesis of 2-amino-5-isopropyl-thiophene-3-carboxylic acid, which is synthesized by reacting isopropylamine with 3-bromothiophene-2-carboxylic acid in the presence of a Lewis acid catalyst, such as aluminum chloride.
Then the 2-amino-5-isopropyl-thiophene-3-carboxylic acid is esterified with ethyl alcohol to produce 2-amino-5-isopropyl-thiophene-3-carboxylic acid ethyl ester.
The final product is a white or slightly yellowish solid with a melting point of around 210-215°C and is used as an intermediate for the production of other chemicals.