The Production Process of 2-Amino-6-chloroimidazo[1,2-b]pyridazine

2-Amino-6-chloroimidazo[1,2-b]pyridazine, also known as ACMP, is an important intermediate in the production of various medications, including antibiotics and anti-inflammatory drugs.
The production process of ACMP involves several steps, which are outlined below.

1. Synthesis of the starting material

The production of ACMP begins with the synthesis of the starting material, which is 2-amino-5-bromopyridine.
This compound is synthesized by reacting 2-aminopyridine with bromine in the presence of a solvent such as chloroform.
The reaction is exothermic, and the product is isolated by filtration and washing with water.

2. Bromination of pyridazine

The next step in the production of ACMP is the bromination of pyridazine, which is also known as 2-pyridazinecarboxylic acid.
This compound is synthesized by reacting pyridazine with bromine in the presence of a solvent such as glacial acetic acid.
The reaction is exothermic, and the product is isolated by filtration and washing with water.

3. Friedel-Crafts reaction

The brominated pyridazine is then treated with chloride in the presence of a Lewis acid catalyst, such as aluminum chloride, to undergo a Friedel-Crafts reaction.
The reaction produces the corresponding chloride, which is isolated by filtration and washing with water.

4. Dehydration

The next step in the production of ACMP is the dehydration of the chloride from step 3.
This is typically accomplished by treating the chloride with a dehydrating agent, such as phosphorus oxychloride.
The reaction is exothermic, and the product is isolated by filtration and washing with water.

5. Nitration

The dehydrated chloride is then treated with nitric acid to undergo a nitration reaction.
The reaction produces the corresponding nitrate, which is isolated by filtration and washing with water.

6. Reduction

The nitrate is then reduced to the corresponding amine using a reducing agent, such as hydrogen gas in the presence of a catalyst, such as palladium on barium sulfate.
The reaction is exothermic, and the product is isolated by filtration and washing with water.

7. Halogenation

The amine produced in step 6 is then treated with chlorine gas to undergo a halogenation reaction.
The reaction produces the corresponding chloride, which is isolated by filtration and washing with water.

8. Cyclization

The final step in the production of ACMP is the cyclization of the chloride from step 7.
This is typically accomplished by treating the chloride with a strong acid, such as sulfuric acid, at a high temperature.
The product of the reaction is the desired ACMP, which is isolated by filtration and washing with water.

Overall, the production process of ACMP involves several steps, including the synthesis of the starting material, bromination, Friedel-Crafts reaction, dehydration, nitration, reduction, halogenation, and cyclization.
The final product is a white crystalline solid that is used as an intermediate in the production of various medications.