The Production Process of 2-Amino-9,9-diphenylfluorene

The production process of 2-amino-9,9-diphenylfluorene is a complex and multi-step process that involves a variety of chemical reaction, separation and purification techniques.
The following is an overview of the production process for 2-amino-9,9-diphenylfluorene, which is widely used in the chemical industry for the production of various chemicals and pharmaceuticals.

Step 1: Synthesis of 2,3-dichloro-5,6-dimethyl-4-oxo-1,2,3,4-tetrahydroquinoline-7-sulphonamide
The first step in the production of 2-amino-9,9-diphenylfluorene involves the synthesis of 2,3-dichloro-5,6-dimethyl-4-oxo-1,2,3,4-tetrahydroquinoline-7-sulphonamide, which is also known as 2,3-dichloro-5,6-dimethyl-7-oxo-1H-quinolin-2-one.
This compound is synthesized by a series of chemical reactions, including the condensation of 2-chloro-5,6-dimethyl-1,4-benzoquinone and 7-amino-1,2,3,4-tetrahydroisoquinoline.

Step 2: Condensation of 2,3-dichloro-5,6-dimethyl-4-oxo-1,2,3,4-tetrahydroquinoline-7-sulphonamide with N-methylaniline
The next step in the production process of 2-amino-9,9-diphenylfluorene involves the condensation of 2,3-dichloro-5,6-dimethyl-4-oxo-1,2,3,4-tetrahydroquinoline-7-sulphonamide with N-methylaniline.
This reaction leads to the formation of N-(2,3-dichloro-5,6-dimethyl-4-oxo-1,2,3,4-tetrahydroquinolin-7-yl)methylamine, which is also known as the N-methylaniline adduct.

Step 3: Hydrolysis of N-methylaniline adduct
The N-methylaniline adduct is then hydrolyzed using acidic or basic hydrolysis techniques.
This results in the cleavage of the amide group, leading to the formation of the corresponding amine.

Step 4: Condensation of N-(2,3-dichloro-5,6-dimethyl-4-oxo-1,2,3,4-tetrahydroquinolin-7-yl)methylamine with 2-fluoro-9,9-diphenylfluorene
The next step in the production process of 2-amino-9,9-diphenylfluorene involves the condensation of N-(2,3-dichloro-5,6-dimethyl-4-oxo-1,2,3,4-tetrahydroquinolin-7-yl)methylamine with 2-fluoro-9,9-diphenylfluorene.
This reaction results in the formation of a new compound, which is a mixture of 2-amino-9,9-diphenylfluorene and its corresponding N-methylaniline adduct.

Step 5: Purification of the product mixture
The product mixture obtained from the condensation reaction is then purified using various techniques such as column chromatography, recrystallization, and spectroscopic analysis.
This step removes any