The Production Process of (2-Chloro-pyrimidin-4-ylmethyl)-isopropyl-amine

The production process of (2-chloro-pyrimidin-4-ylmethyl)-isopropyl-amine, commonly referred to as ACE-039, is a complex and multi-step process that involves various chemical reactions and purification steps.
The final product is an intermediate chemical used in the production of some pharmaceuticals and agrochemicals.

The production process of ACE-039 can be broken down into the following stages:

1. Preparation of the starting materials: The production process of ACE-039 begins with the preparation of the starting materials, which include pyrimidine-2,4-diamine, 2-chloro-1,3-dimethyl-5-phenyl pyrimidin-4-amine hydrochloride, and isopropyl amine.
   These starting materials are synthesized using various chemical reactions and purification steps, which are beyond the scope of this article.
   
2. Condensation reaction: The preparation of ACE-039 involves a condensation reaction between pyrimidine-2,4-diamine and 2-chloro-1,3-dimethyl-5-phenyl pyrimidin-4-amine hydrochloride in the presence of a condensing agent, such as dicyclohexylcarbodiimide (DCC).
   The reaction is carried out in a solvent such as dichloromethane or chloroform, under anhydrous conditions.
   The condensation reaction results in the formation of an intermediate compound, which is then purified by dissolving it in a solvent such as toluene and washing it with water.
   
3. Reduction reaction: The intermediate compound obtained from the condensation reaction is then reduced using a reducing agent such as lithium aluminum hydride (LiAlH4) in the presence of a solvent such as ether.
   The reduction reaction results in the formation of the final product, (2-chloro-pyrimidin-4-ylmethyl)-isopropyl-amine.
   
4. Purification: The final product is purified by dissolving it in a solvent such as ethyl acetate and washing it with a solution of sodium bicarbonate and water.
   The organic layer is then dried with anhydrous sodium sulfate and concentrated to obtain a pure sample of ACE-039.
   

In conclusion, the production process of ACE-039 involves various chemical reactions and purification steps.
The process begins with the preparation of the starting materials and ends with the purification of the final product.
The purity and quality of the final product are crucial for its use as an intermediate in the production of some pharmaceuticals and agrochemicals.
It is important to ensure that the entire production process is carried out in a controlled environment and that all the safety precautions are taken to prevent any accidents or harm to the workers.