The Production Process of 2H-Thieno[3,2-e]-1,2-thiazine-6-sulfonamide, 3,4-dihydro-4-hydroxy-2-(3-methoxypropyl)-, 1,1-dioxide, (4S)-

The Production Process of 2H-Thieno[3,2-e]-1,2-thiazine-6-sulfonamide, 3,4-dihydro-4-hydroxy-2-(3-methoxypropyl)-, 1,1-dioxide, (4S)-

2H-Thieno[3,2-e]-1,2-thiazine-6-sulfonamide, 3,4-dihydro-4-hydroxy-2-(3-methoxypropyl)-, 1,1-dioxide, also known as (4S)-4-[(3-methoxypropyl)sulfonyl]-2H-thieno[3,2-e][1,2-thiazine-6sulfonamide, is a unique compound that has numerous applications in various fields such as pharmaceuticals, agrochemicals, and organic synthesis.
The compound is synthesized through a multi-step process that involves the use of various reagents, solvents, and chemicals.
This article will provide a detailed overview of the production process of (4S)-4-[(3-methoxypropyl)sulfonyl]-2H-thieno[3,2-e][1,2-thiazine-6sulfonamide.

Step 1: Preparation of 2H-thieno[3,2-e][1,2-thiazine-6-sulfenamide, 3,4-dihydro-4-hydroxy-

The production of (4S)-4-[(3-methoxypropyl)sulfonyl]-2H-thieno[3,2-e][1,2-thiazine-6sulfonamide starts with the preparation of 2H-thieno[3,2-e][1,2-thiazine-6-sulfenamide, 3,4-dihydro-4-hydroxy- (1).
This compound can be synthesized by reaction of 2H-thieno[3,2-e][1,2-thiazine-6-amine (2) with sodium hydroxide and sodium nitrite in the presence of a solvent such as water or acetonitrile.
The reaction is exothermic, and it should be carried out with adequate precautions to avoid accidents.

Step 2: Preparation of 3,4-dihydro-4-hydroxy-2-(3-methoxypropyl)benzaldehyde

The next step involves the synthesis of 3,4-dihydro-4-hydroxy-2-(3-methoxypropyl)benzaldehyde (3), which is prepared by the reaction of 3-methoxypropylbenzaldehyde (4) with hydroxylamine in the presence of a solvent such as methanol or ethanol.
The reaction is acidified with a strong acid such as sulfuric acid to promote the reaction.

Step 3: Preparation of 4-[(3-methoxypropyl)sulfonyl]-2H-thieno[3,2-e][1,2-thiazine-6sulfonamide

The final step involves the synthesis of (4S)-4-[(3-methoxypropyl)sulfonyl]-2H-thieno[3,2-e][1,2-thiazine-6sulfonamide (5) by reaction of 3,4-dihydro-4-hydroxy-2-(3