The Production Process of 3,4,5,6,7,8-HEXAHYDRO-2(1H)-QUINOLINONE

The production process of 3,4,5,6,7,8-hexahydro-2(1H)-quinolinone is a multi-step process that involves several chemical reactions and purification steps.
In the chemical industry, the production process of 3,4,5,6,7,8-hexahydro-2(1H)-quinolinone is crucial for the production of various pharmaceuticals, agricultural chemicals, and other specialty chemicals.
This article provides an overview of the production process of 3,4,5,6,7,8-hexahydro-2(1H)-quinolinone, including the various chemical reactions involved and the purification steps required to obtain a pure sample of the final product.

Step 1: Preparation of N-Chlorosuccinimide
The first step in the production of 3,4,5,6,7,8-hexahydro-2(1H)-quinolinone is the preparation of N-chlorosuccinimide.
This compound is prepared by reactingsuccinic acid with chlorine gas in the presence of a Lewis acid catalyst, such as aluminum chloride.
The reaction can be represented as follows:

Succinic acid + Cl2 + AlCl3 → N-Chlorosuccinimide

Step 2: Hydrolysis of N-Chlorosuccinimide
The next step in the production of 3,4,5,6,7,8-hexahydro-2(1H)-quinolinone is the hydrolysis of N-chlorosuccinimide.
This step is carried out by treating N-chlorosuccinimide with water in the presence of a strong acid catalyst, such as sulfuric acid.
The reaction can be represented as follows:

N-Chlorosuccinimide + H2O → N-Hydroxysuccinimide

Step 3: Nitration of N-Hydroxysuccinimide
The next step in the production of 3,4,5,6,7,8-hexahydro-2(1H)-quinolinone is the nitration of N-hydroxysuccinimide.
This step is carried out by treating N-hydroxysuccinimide with nitric acid.
The reaction can be represented as follows:

N-Hydroxysuccinimide + HNO3 → N-Nitrosocyclohexane-carboxylic acid

Step 4: Ring-closing metathesis of N-Nitrosocyclohexane-carboxylic acid
The next step in the production of 3,4,5,6,7,8-hexahydro-2(1H)-quinolinone is the ring-closing metathesis of N-nitrosocyclohexane-carboxylic acid.
This step is carried out by treating N-nitrosocyclohexane-carboxylic acid with a metal catalyst, such as ruthenium or molybdenum, in the presence of a ligand, such as cobalt octoate.
The reaction can be represented as follows:

N-Nitrosocyclohexane-carboxylic acid + N-Nitrosocyclohexane-carboxylic acid → 3,4,5,6,7,8-hexahydro-2(1H)-quinolinone

Step 5: Purification of 3,4,5,6,7,8-hexahydro-2(1H)-quinolinone
After the ring-closing metathesis reaction, the final product, 3,4,5,6,7,8-hexahydro-2(1H)-quinolinone, must be purified to obtain a pure sample of the final product