The Production Process of 3-Chloro-6-(piperidin-3-yloxy)-pyridazine hydrochloride, 98+% C9H13Cl2N3O, MW: 250.12

The production process of 3-Chloro-6-(piperidin-3-yloxy)-pyridazine hydrochloride, also known as MK-8016, involves several steps that must be carefully controlled in order to obtain the desired product in high purity.
The starting materials and reagents used in the synthesis must also be of high quality to ensure that the final product meets the required specifications.

Step 1: Synthesis of 6-(piperidin-3-yloxy)-pyridazine-3-carboxylic acid
The first step in the synthesis of MK-8016 involves the synthesis of 6-(piperidin-3-yloxy)-pyridazine-3-carboxylic acid.
This is accomplished by reacting 3-chloro-pyridazine-2,6-dicarboxylic acid with piperidine in the presence of a solvent such as dimethylformamide (DMF).
The reaction is typically carried out at a temperature of around 100-120°C for several hours with stirring.

Step 2: Condensation of 6-(piperidin-3-yloxy)-pyridazine-3-carboxylic acid with 3-chloro-pyridazine-2,6-dicarboxylic acid
The next step in the synthesis of MK-8016 involves the condensation of 6-(piperidin-3-yloxy)-pyridazine-3-carboxylic acid with 3-chloro-pyridazine-2,6-dicarboxylic acid.
This is typically done by heating the two starting materials in the presence of a strong acid catalyst such as hydrochloric acid at a temperature of around 150-170°C for several hours.

Step 3: Dehydration of the product
After the condensation reaction is complete, the product is typically dehydrated using a solvent such as sulfuric acid.
The reaction is typically carried out at a temperature of around 80-100°C for several hours with stirring.

Step 4: Hydrolysis of the intermediate
The next step in the synthesis of MK-8016 involves the hydrolysis of the intermediate to form the final product.
This is typically done by treating the intermediate with a strong base such as sodium hydroxide at a temperature of around 50-70°C for several hours.

Step 5: Purification of the product
Finally, the final product is purified using a variety of methods such as crystallization, filtration, and chromatography.
The purified product is then dried and characterized to ensure that it meets the required specifications.

In conclusion, the production process of 3-Chloro-6-(piperidin-3-yloxy)-pyridazine hydrochloride involves several steps that must be carefully controlled in order to obtain the desired product in high purity.
The starting materials and reagents used in the synthesis must also be of high quality to ensure that the final product meets the required specifications.
The key steps in the synthesis include the synthesis of 6-(piperidin-3-yloxy)-pyridazine-3-carboxylic acid, condensation of 6-(piperidin-3-yloxy)-pyridazine-3-carboxylic acid with 3-chloro-pyridazine-2,6-dicarboxylic acid, dehydration of the product, hydrolysis of the intermediate, and purification of the final product.