The Production Process of 3-CHLORO-6-PYRROLIDIN-1-YL-PYRIDAZINE

The production process of 3-chloro-6-pyrrolidin-1-yl-pyridazine involves a series of chemical reactions that transform the starting materials into the desired product.
This compound is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals.
The following is an overview of the production process of 3-chloro-6-pyrrolidin-1-yl-pyridazine.

Step 1: Synthesis of Pyrrolidine-1,3-dione
The first step in the production of 3-chloro-6-pyrrolidin-1-yl-pyridazine involves the synthesis of pyrrolidine-1,3-dione from 3-chlorpropanol and ammonia.
This reaction is catalyzed by a strong acid catalyst such as sulfuric acid and is typically carried out in a solvent such as water or a polar organic solvent.
The reaction is exothermic, and the mixture must be cooled to prevent excessive heating.

Step 2: Nitration of Pyrrolidine-1,3-dione
In the second step, the pyrrolidine-1,3-dione is nitrated with nitric acid to form 3-nitro-6-pyrrolidin-1-yl-pyridazine.
This reaction is typically carried out in the presence of a solvent such as acetonitrile or DMF, and is often catalyzed by a small amount of oxalic acid or another suitable catalyst.
The reaction temperature is typically around 80-100°C.

Step 3: Reduction of 3-nitro-6-pyrrolidin-1-yl-pyridazine
The next step is the reduction of the nitro group in 3-nitro-6-pyrrolidin-1-yl-pyridazine to form 3-chloro-6-pyrrolidin-1-yl-pyridazine.
This reduction can be achieved using a reducing agent such as hydrogen gas or a metal hydride such as lithium aluminum hydride.
The reduction is typically carried out in the presence of a solvent such as ethanol or isopropanol, and the reaction is typically performed at room temperature.

Step 4: Purification of 3-chloro-6-pyrrolidin-1-yl-pyridazine
The final step in the production of 3-chloro-6-pyrrolidin-1-yl-pyridazine is the purification of the synthesized compound.
This can be achieved using standard methods such as crystallization, chromatography, or recrystallization.
The pure compound is then collected and dried, ready for use in the next stage of the synthesis process.

Overall, the production process of 3-chloro-6-pyrrolidin-1-yl-pyridazine involves a series of well-established chemical reactions that are widely used in the pharmaceutical and agrochemical industries.
However, it is important to note that the specific conditions and reagents used can vary depending on the scale of production and the desired purity of the final product.
Therefore, it is essential to consult with an experienced chemist or chemical engineer to optimize the production process for a given application.