The Production Process of 3-Pyridinamine,2,6-difluoro-(9CI)

The production process of 3-pyridinamine, 2,6-difluoro- (9CI) involves a series of chemical reactions that convert raw materials into the desired product.
The following is a detailed overview of the production process for this compound.

Step 1: Preparation of the starting material
The production process of 3-pyridinamine, 2,6-difluoro- (9CI) begins with the preparation of the starting material, which involves the reaction of 2,6-difluoropyridine with hydroxylamine.
This reaction is carried out in a suitable solvent, such as water or ethanol, at a temperature of around 80-100°C and with a concentration of the reactants of approximately 1-2 moles/L.
The reaction produces 3-pyridinamine, 2,6-difluoro-, which is the starting material for the next step in the production process.

Step 2: Reduction of the nitro group
The next step in the production process is the reduction of the nitro group of the starting material.
This is achieved by treating the material with a reducing agent such as hydriodide (HI) in the presence of a solvent such as sodium hydroxide.
The reaction is carried out at a temperature of around 70-80°C and with a concentration of the reactants of approximately 1-2 moles/L.
This reaction converts the nitro group to an amino group, producing the intermediate product 3-pyridinecarboxamide, 2,6-difluoro-.

Step 3: Deprotection of the amine group
The next step in the production process is the deprotection of the amine group of the intermediate product.
This is achieved by treating the material with a strong base such as sodium hydroxide in a suitable solvent, such as water or ethanol.
The reaction is carried out at a temperature of around 50-60°C and with a concentration of the reactants of approximately 1-2 moles/L.
This reaction converts the amine group to a primary amine, producing the final product 3-pyridinamine, 2,6-difluoro-.

The production process of 3-pyridinamine, 2,6-difluoro- (9CI) involves a series of chemical reactions that convert raw materials into the desired product.
The process begins with the preparation of the starting material and continues with the reduction of the nitro group, the deprotection of the amine group, and finally the dehydration of the intermediate product.
The final product is 3-pyridinamine, 2,6-difluoro- (9CI), which is widely used in the pharmaceutical and chemical industries for various applications.