The Production Process of (4-Chloro-pyrimidin-2-yl)-cyclopropyl-amine

The production process of (4-chloro-pyrimidin-2-yl)-cyclopropyl-amine is a complex and multi-step process that involves several chemical reactions and purification steps.
The following is an overview of the production process for (4-chloro-pyrimidin-2-yl)-cyclopropyl-amine:

Step 1: Preparation of Starting Materials
The production process of (4-chloro-pyrimidin-2-yl)-cyclopropyl-amine begins with the preparation of starting materials.
This involves the synthesis of 2-chloropyrimidine and cyclopropylamine, which are then reacted to form the desired product.

Step 2: Nitric Acid Hydrolysis
The next step in the production process is nitric acid hydrolysis, which involves the hydrolysis of the cyclopropylamine using nitric acid to form the corresponding amide and a secondary amine.

Step 3: Hydrogenation
The secondary amine obtained from the nitric acid hydrolysis is then subjected to hydrogenation to reduce the nitrogen atom to an amine group.
This step involves the addition of hydrogen gas to the reaction mixture, often in the presence of a catalyst such as Pd/C.

Step 4: Reduction
Next, the amine is reduced to form the final product (4-chloro-pyrimidin-2-yl)-cyclopropyl-amine.
This step typically involves the use of a reducing agent such as lithium aluminum hydride (LiAlH4) or hydrogen in the presence of a catalyst.

Step 5: Purification
After the production of (4-chloro-pyrimidin-2-yl)-cyclopropyl-amine, the product is typically purified using a variety of techniques such as crystallization, filtration, and chromatography.
This step is important for the removal of any impurities and for ensuring the purity of the final product.

Overall, the production process of (4-chloro-pyrimidin-2-yl)-cyclopropyl-amine involves several chemical reactions and purification steps.
Each step must be carefully controlled and monitored to ensure the production of a high-quality final product.
The production process can also be adjusted based on the scale of production to ensure efficient and cost-effective production.