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The Production Process of (4R,12aS)-N-(2,4-difluorobenzyl)-7-benzylhydroxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxaMide

 Last Update: 2023-05-07
 Source: Internet
 Author: User

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Title: The Production Process of (4R,12aS)-N-(2,4-difluorobenzyl)-7-benzylhydroxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, an Emerging Antiviral Drug

Abstract:

The rising global concern over the COVID-19 pandemic has led to a renewed focus on antiviral drug development.
One such promising antiviral compound is (4R,12aS)-N-(2,4-difluorobenzyl)-7-benzylhydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, a synthetic antiviral drug currently under development by pharmaceutical company XYZ.
This article provides an overview of the production process for (4R,12aS)-N-(2,4-difluorobenzyl)-7-benzylhydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, from its synthesis to its final formulation.

Introduction:

The ongoing COVID-19 pandemic has highlighted the urgent need for new antiviral drugs to combat emerging infectious diseases.
(4R,12aS)-N-(2,4-difluorobenzyl)-7-benzylhydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide (hereafter referred to as "the drug") is a promising antiviral compound currently under development by pharmaceutical company XYZ.
The drug has shown potent activity against a wide range of viruses, including SARS-CoV-2, the virus responsible for the COVID-19 pandemic.

Synthesis of the Drug:

The synthesis of the drug involves a multi-step process that involves the synthesis of several key intermediates.
The synthesis of the drug can be broken down into the following steps:

Step 1: Synthesis of 2,4-difluorobenzyl alcohol

The synthesis of 2,4-difluorobenzyl alcohol involves the reaction of 2,4-difluorobenzyl chloride with sodium hydroxide in the presence of a solvent such as DMF.
The reaction results in the formation of 2,4-difluorobenzyl alcohol, which is then employed in the next step of the synthesis.

Step 2: Synthesis of 7-benzylhydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid

The synthesis of 7-benzylh

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