The Production Process of 5H-Cyclopentapyrimidin-2-amine, 6,7-dihydro- (9CI)

The Production Process of 5H-Cyclopentapyrimidin-2-amine, 6,7-dihydro- (9CI)

In the chemical industry, the production of various chemical compounds is a complex process that involves multiple steps.
The production of 5H-Cyclopentapyrimidin-2-amine, 6,7-dihydro- (9CI) is no exception.
This compound is commonly used as an intermediate in the production of various pharmaceuticals and agrochemicals.
In this article, we will discuss the production process of 5H-Cyclopentapyrimidin-2-amine, 6,7-dihydro- (9CI) in detail.

Step 1: Raw Material Preparation
The production of 5H-Cyclopentapyrimidin-2-amine, 6,7-dihydro- (9CI) begins with the preparation of raw materials.
The key raw material for the production of this compound is 2-chloropyrimidine, which is obtained by chlorination of pyridine.
Other raw materials such as lime, hydrochloric acid, and water are also used in the production process.

Step 2: Hydrolysis
The next step in the production process is hydrolysis.
In this step, the 2-chloropyrimidine is treated with lime and water to produce 2-amino-6,7-dihydro-5H-pyrimidine.
This reaction is exothermic and requires careful monitoring to prevent overheating.

Step 3: Nitration
The 2-amino-6,7-dihydro-5H-pyrimidine obtained from the hydrolysis step is further nitrated with nitric acid to produce 2-nitro-6,7-dihydro-5H-pyrimidine.
This reaction also requires careful monitoring to prevent overheating.

Step 4: Reduction
The 2-nitro-6,7-dihydro-5H-pyrimidine produced in the nitration step is reduced to 2-amino-6,7-dihydro-5H-pyrimidine using a reducing agent such as hydrazine.
This step is carried out at a lower temperature to prevent the reversion of the nitro group to the amino group.

Step 5: Ring Closure
The final step in the production process is ring closure.
In this step, the 2-amino-6,7-dihydro-5H-pyrimidine is treated with an alkali metal carbonate, such as sodium carbonate, to close the ring and form 5H-Cyclopentapyrimidin-2-amine, 6,7-dihydro- (9CI).

Quality Control

The quality of the final product is critical in the production process.
To ensure the quality of the final product, various tests are carried out at different stages of production.
These tests include:

• Physical tests such as melting point, boiling point, and solubility.
  
• Chemical tests such as elemental analysis, ash test, and residue on ignition.
  
• Spectroscopic tests such as infrared spectroscopy and nuclear magnetic resonance spectroscopy.
  

Conclusion

The production process of 5H-Cyclopentapyrimidin-2