The Production Process of 6-Bromomethylisoquinoline hydrobromide

The production process of 6-bromomethylisoquinoline hydrobromide is a multi-step process that involves several chemical reactions and purification steps.
The following is a detailed overview of the production process of 6-bromomethylisoquinoline hydrobromide.

Step 1: Synthesis of 4-chloro-6-methylpyridine
The synthesis of 4-chloro-6-methylpyridine is the first step in the production process of 6-bromomethylisoquinoline hydrobromide.
4-chloro-6-methylpyridine is synthesized by reacting 6-methylpyridine with sodium hypochlorite in the presence of a solvent, such as water or methanol.
This reaction is exothermic, and the mixture is stirred to dissipate the heat.
The resulting mixture is then filtered to remove any solids, and the filtrate is concentrated under reduced pressure to obtain a solid residue.
The residue is then recrystallized from a suitable solvent, such as ethanol or acetone, to obtain pure 4-chloro-6-methylpyridine.

Step 2: Synthesis of 2-cyanopyridine
The synthesis of 2-cyanopyridine is the second step in the production process of 6-bromomethylisoquinoline hydrobromide.
2-cyanopyridine is synthesized by reacting 4-chloro-6-methylpyridine with sodium cyanide in the presence of a solvent, such as water or acetone.
This reaction is exothermic, and the mixture is stirred to dissipate the heat.
The resulting mixture is then filtered to remove any solids, and the filtrate is concentrated under reduced pressure to obtain a solid residue.
The residue is then purified by recrystallization from a suitable solvent, such as ethanol or acetone, to obtain pure 2-cyanopyridine.

Step 3: Synthesis of 2-(2-cyanopyridine)benzaldehyde
The synthesis of 2-(2-cyanopyridine)benzaldehyde is the third step in the production process of 6-bromomethylisoquinoline hydrobromide.
2-(2-cyanopyridine)benzaldehyde is synthesized by reacting 2-cyanopyridine with benzaldehyde in the presence of a solvent, such as dichloromethane or toluene.
This reaction is exothermic, and the mixture is stirred to dissipate the heat.
The resulting mixture is then filtered to remove any solids, and the filtrate is concentrated under reduced pressure to obtain a solid residue.
The residue is then purified by recrystallization from a suitable solvent, such as ethanol or acetone, to obtain pure 2-(2-cyanopyridine)benzaldehyde.

Step 4: Synthesis of N-(6-bromomethyl-2-oxo-1,2-oxazolidin-3-ylidenamino)benzamide
The synthesis of N-(6-bromomethyl-2-oxo-1,2-oxazolidin-3-ylidenamino)benzamide is the fourth step in the production process of 6-bromomethylisoquinoline hydrobromide.
N-(6-bromomethyl-2-oxo-1,2-oxazolidin-3-ylidenamino)benzamide is synthesized by reacting 2-(2-cyanopyridine)benzaldehyde with N-(6-bromomethyl-