The Production Process of (6-Chloro-pyridazin-3-yl)-piperidin-4-yl-aMine hydrochloride, 98+% C9H14Cl2N4, MW: 249.14

The production process of (6-Chloro-pyridazin-3-yl)-piperidin-4-yl-amine hydrochloride, also known as compound C9H14Cl2N4, is a complex and multi-step process that involves various chemical reactions and purification techniques.
The final product is a white to off-white powder with a melting point of 210-215°C and a molecular weight of 249.
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The process begins with the synthesis of the starting material, which is a combination of pyridazine and piperidine.
These two compounds are reacted together in the presence of a strong acid catalyst to form the initial reaction product, which is then purified through a series of chromatography steps to remove any impurities.

The purified reaction product is then treated with hydrogen chloride gas to convert it into the hydrochloride salt form, which is the final product.
This step also involves the removal of any remaining impurities, including water and organic solvents.

The key reaction in the production process of (6-Chloro-pyridazin-3-yl)-piperidin-4-yl-amine hydrochloride is the condensation of pyridazine and piperidine to form the initial reaction product.
This reaction is typically carried out in a solution of a suitable solvent, such as acetonitrile or DMF, in the presence of a strong acid catalyst, such as sulfuric acid or phosphoric acid.

The temperature and reaction time for this reaction are carefully controlled to ensure the desired yield and purity of the product.
The reaction mixture is then purified through a series of chromatography steps, including high-performance liquid chromatography (HPLC) and flash chromatography, to remove any impurities and isolate the pure product.

The purified reaction product is then treated with hydrogen chloride gas to convert it into the hydrochloride salt form.
This step is typically carried out in the presence of a suitable solvent, such as ethanol or methanol, to facilitate the reaction.
The reaction mixture is then purified through additional chromatography steps to remove any remaining impurities and isolate the pure product.

The final product is a white to off-white powder with a melting point of 210-215°C and a molecular weight of 249.
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The purity of the final product is typically greater than 98%, as determined by high-performance liquid chromatography (HPLC) or another appropriate analytical technique.

In conclusion, the production process of (6-Chloro-pyridazin-3-yl)-piperidin-4-yl-amine hydrochloride is a complex and multi-step process that involves various chemical reactions and purification techniques.
The final product is a white to off-white powder with a melting point of 210-215°C and a molecular weight of 249.
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The purity of the final product is typically greater than 98%, making it a valuable intermediate or starting material for the synthesis of other pharmaceutical compounds.