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Atovaquone is an antimalarial drug that is used to treat malaria in adults and children.
It is also used to prevent malaria in people who are traveling to areas where malaria is common.
The production process of atovaquone involves several steps, including the synthesis of the basic compound, the conversion of the basic compound into atovaquone, and the purification of the final product.
The first step in the production process is the synthesis of the basic compound, which is called 4-chloro-8-fluoro-1,2,4-trioxo-1,2,4-triazine.
This compound is synthesized by reacting chloral hydrate with sodium hydroxide and then treating the resulting solution with ammonia and hydrochloric acid.
The resulting compound is then purified by crystallization and washed with water.
The next step is the conversion of the basic compound into atovaquone.
This involves a series of chemical reactions that are carried out in several stages.
The first stage involves the treatment of the basic compound with hydrochloric acid and the addition of sodium nitrite.
This is followed by the addition of water and the extraction of the product with chloroform.
The organic phase is then washed with water and saturated aqueous sodium bicarbonate, and dried over anhydrous sodium sulfate.
The solvent is then removed under vacuum, and the resulting residue is treated with aqueous sodium hydroxide and then extracted with ether.
The ether solution is then washed with water and dried over anhydrous sodium sulfate.
The final step in the production process is the purification of the final product.
This involves the crystallization of atovaquone from ethanol, followed by washing with water and drying under vacuum.
The purified product is then crushed and passed through a 20-mesh sieve.
In summary, the production process of atovaquone involves several steps, including the synthesis of the basic compound, the conversion of the basic compound into atovaquone, and the purification of the final product.
The final product is a white to off-white crystalline powder that is used as an antimalarial drug.
