echemi logo
  • Product
  • Supplier
  • Inquiry
    Home > Active Ingredient News > Antitumor Therapy > The Production Process of Bortezomib

    The Production Process of Bortezomib

    • Last Update: 2023-05-12
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit

    Bortezomib is a medication used to treat cancer, specifically multiple myeloma and mantle cell lymphoma.
    It is a proteasome inhibitor, which means that it blocks the action of proteasomes, which are enzymes that break down proteins in cells.
    By inhibiting the proteasome, bortezomib causes the cells to die, which can help to slow the growth of cancer cells.

    The production process of bortezomib involves several steps, from the preparation of the starting materials to the final product.

    1. Synthesis of the boronate ester: The first step in the production of bortezomib is the synthesis of a boronate ester.
      This compound is made by reacting boric acid with a fatty acid, such as chloroformic acid.
      The boronate ester is then treated with a compound called a phenol, which is used to create the bortezomib molecule.
    2. Condensation reaction: The boronate ester and the phenol are then reacted in a condensation reaction, which produces a intermediate compound.
      This reaction is catalyzed by a chemical called a condensing agent, which helps to join the boronate ester and the phenol molecules together.
    3. Amination reaction: The intermediate compound is then treated with an amine in an amination reaction.
      This reaction adds a nitrogen atom to the molecule, which helps to create the final structure of bortezomib.
    4. Purification: After the amination reaction, the bortezomib molecule is purified to remove any unwanted impurities.
      This is typically done through a process called chromatography, which separates the bortezomib molecules based on their physical properties.
    5. Formulation: The final step in the production of bortezomib is the formulation of the medication.
      This involves mixing the pure bortezomib with other substances, such as excipients and preservatives, to create the final product.
      The formulation process is done in a sterile facility to ensure that the medication is free from contaminants.

    Overall, the production process of bortezomib involves several steps, from the synthesis of the boronate ester to the formulation of the final medication.
    Each step must be carefully controlled and monitored to ensure that the final product is safe and effective for use in patients.

    This article is an English version of an article which is originally in the Chinese language on and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to with relevant evidence.