The Production Process of FOLINIC ACID CALCIUM SALT PENTAHYDRATE

Folinic acid calcium salt pentaerythrityl tetrahydrate, also known as calcium folinate or folinic acid calcium salt, is a compound that is used as a nutritional supplement and as a pharmaceutical agent.
It is a form of folic acid, a B vitamin that is essential for cell growth and development.
The production process of folinic acid calcium salt pentaerythrityl tetrahydrate involves several steps, including the synthesis of folic acid, the formation of the calcium salt, and the production of the pentaerythrityl tetrahydrate crystalline form.

The synthesis of folic acid involves the reaction of para-aminobenzoic acid (PABA) with a series of compounds, including glycine, D-glutamic acid, and 5-formyltetrahydrofolate (5-FTHF).
The reaction of PABA with 5-FTHF produces folic acid, which is then purified and converted into the calcium salt form.

The formation of the calcium salt involves the reaction of folic acid with calcium hydroxide.
This reaction produces a calcium salt of folic acid, which is then purified and dried.
The resulting calcium salt is a fine, white powder that is used as a starting material in the production of the pentaerythrityl tetrahydrate form.

To produce the pentaerythrityl tetrahydrate form, the calcium salt isSubject to a series of chemical reactions and processing steps, including esterification and crystallization.
In the esterification step, the calcium salt is reacted with pentaerythritol and a strong acid catalyst, such as hydrochloric acid, to form the ester.
The ester is then treated with a base, such as sodium hydroxide, to produce the pentaerythrityl tetrahydrate crystalline form.

The production process of folinic acid calcium salt pentaerythrityl tetrahydrate involves several steps, including the synthesis of folic acid, the formation of the calcium salt, and the production of the pentaerythrityl tetrahydrate crystalline form.
This compound is used as a nutritional supplement and as a pharmaceutical agent, and the production process requires a combination of chemical reactions and processing steps to produce the final product.
The resulting compound is a fine, white powder that is used in a variety of applications in the pharmaceutical and nutraceutical industries.