The Production Process of Isonicotinic acid N-oxide

Isonicotinic acid N-oxide (INO), also known as isonicotinamide N-oxide, is a white or slightly yellow crystalline solid that is commonly used in the chemical industry as a catalyst for the production of other chemicals.
The production process for INO involves several steps, including the synthesis of the starting materials, the oxidation of the starting materials to form INO, and the purification of the resulting INO product.

The synthesis of the starting materials for the production of INO typically involves the reaction of epichlorohydrin and p-toluenesulfonyl chloride in the presence of a catalyst, such as sodium hydroxide or potassium hydroxide.
This reaction produces a mixture of compounds, including the starting material for INO, N-(2,6-dimethylphenyl)oxamide.

The oxidation of the starting material to form INO typically involves the use of a strong oxidizing agent, such as chromic acid or pyridinium chloride.
This reaction converts the starting material into INO, which can then be isolated and purified.

The purification of INO typically involves the use of chemical techniques, such as crystallization or recrystallization, to remove impurities and obtain a pure INO product.
The purified INO product can then be used as a catalyst in the production of other chemicals.

Overall, the production process for INO involves several steps, including the synthesis of the starting materials, the oxidation of the starting materials to form INO, and the purification of the resulting INO product.
INO is an important intermediate in the production of other chemicals and is widely used in the chemical industry.