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The production process of N-[3-[5-(2-Chloro-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide involves several steps, from the preparation of raw materials to the final product.
The following is a detailed description of the production process.
- Preparation of raw materials: The production of N-[3-[5-(2-Chloro-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide involves the use of several raw materials, including 2,6-difluorobenzenesulfonamide, N-[3-[5-(2-chloro-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]amine, and pyridine hydrochloride.
The raw materials are produced in a laboratory setting, and their purity and quality are carefully controlled to ensure the success of the production process. - Synthesis of N-[3-[5-(2-Chloro-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide: The synthesis of N-[3-[5-(2-Chloro-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide begins with the synthesis of N-[3-[5-(2-chloro-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]amine.
This is achieved by reacting 2-fluorophenylamine hydrochloride with 2-chloro-4-pyrimidinecarboxaldehyde, followed by the addition of N-[2-(1,1-dimethylethyl)-4-thiazolyl]thiourea to the resulting intermediate.
The resulting N-[3-[5-(2-chloro-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]amine is then reacted with 2,6-difluorobenzenesulfonamide in the presence of pyridine hydrochloride and triethylamine.
The resulting product is then purified using standard methods, such as recrystallization, to remove any impurities and ensure the purity of the final product.
- Purification and characterization of N-[3-[5-(2-Chloro-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide: After the synthesis and reaction steps, the product is purified using recrystallization and then characterized using various analytical techniques, such as high-performance liquid chromatography (HPLC), nuclear magnetic resonance spectroscopy (NMR), and mass spectrometry (MS).
These techniques are used to confirm the identity of the product and to determine its purity and molecular weight.
The final product is then packaged and labeled according to the specific requirements of the intended use,
