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The production process of Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester, also known as Compound 1, is a complex and multi-step process that involves various chemical reactions and purification steps.
The final product, Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester, is a key intermediate for the synthesis of several important pharmaceuticals and agricultural chemicals.
The production process of Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester can be divided into several stages, including:
- Synthesis of N-ferrocene carboxamide
The first step in the production of Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester is the synthesis of N-ferrocene carboxamide, which is synthesized by reacting ferrocene with ammonia in the presence of a strong acid catalyst, such as sulfuric acid. - Condensation reaction with ethyl acrylate
Next, N-ferrocene carboxamide is reacted with ethyl acrylate in the presence of a condensation catalyst, such as a base, to form Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester. - Purification of the product
The product from the condensation reaction is then purified by various methods, including distillation, crystallization, and chromatography, to remove any impurities and to obtain a pure sample of Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester. - Hydrolysis of the ester
Finally, the Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester is hydrolyzed by treatment with a strong acid, such as hydrochloric acid, to form the free acid.
In summary, the production process of Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester involves the synthesis of N-ferrocene carboxamide, followed by a condensation reaction with ethyl acrylate, purification of the product, and finally hydrolysis of the ester to form the free acid.
This process requires a combination of chemical reactions and purification steps to obtain a pure sample of the final product, which is used as a key intermediate in the synthesis of various pharmaceuticals and agricultural chemicals.
