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While probing one of biology's deepest unanswered questions, a team led by Rutgers University has discovered the structure of a protein that may have led to the origin of life in the primordial soup of ancient Earth
.
The research was recently published in the journal Science Advances
Researchers exploring how primitive life arose from simple inanimate materials on our planet have concluded that anything living needs to collect and use energy from sources such as the sun or hydrothermal vents
.
In molecular terms, this means that the ability to transfer electrons is critical to life
.
Since the best elements for electron transfer are metals, and most biological activity is carried out by proteins, the researchers decided to explore the combination of the two, the metal-binding proteins
They compared all existing metal-bound protein structures to establish any common features that were present in ancestral proteins and that were diversified and passed down to create the numerous proteins we see today
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The evolution of protein structure requires understanding how new folds arise from pre-existing folds, so the researchers devised a computational approach and found that the vast majority of metal-binding proteins that exist today are somewhat similar, regardless of the type of metal they bind
.
The metal-binding cores of existing proteins are indeed all similar, although the proteins themselves may not be similar, said study lead author Yana Bromberg, a professor in the Department of Biochemistry and Microbiology at Rutgers University New Brunswick
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These metal-bonded cores typically consist of repeating substructures, a bit like Lego bricks
"We know very little about how life arose on this planet, and our work provides an explanation that wasn't available before," Bromberg said.
"
This explanation may help us search for other planets and planetary bodies.
Life
Editor-in-Chief
What was the first protein in the origin of life? Scientists have been trying to solve this mystery
.
Human beings always like to get to the bottom of things and want to know how everything started in the first place