The research team of the National Edible Fungus Center of Henan University has made progress in the application of durian skin

Editor in charge: Food Science

“Mechanism of intestinal flora and proteomics in regulating immune function of Durio Zibethinus rind polysaccharide” is the result of the collaboration between the food dual-use resource research team of the National Edible Fungus Processing Technology Research and Development Center and the Hebei Food Inspection Research Institute/Hebei Medical University Forensic Medicine Researcher Zhang Yan’s team Recently, it was published in the journal "Oxidative Medicine and Cellular Longevity" (immediate IF: 5.

Durio ( Durio zibethinus Murr) is the fruit of durian, an evergreen tree in the genus Durian of the Ceiba family.

This study used cyclophosphamide (CTX) administration to establish an immunosuppressive mouse model.

The results show that compared with the model group, the durian skin polysaccharide high-dose group (200 mg/kg) can significantly increase the thymus and spleen index and improve the spleen tissue structure; significantly increase the cytokines interleukin-2 (IL-2) and interleukin- 4 (IL-4), interleukin-6 (IL-6) and tumor necrosis factor- α (TNF- α ) content; increase serum acid phosphatase (ACP), lactate dehydrogenase (LDH), superoxide dismutation Enzyme (SOD) and total antioxidant capacity (T-AOC) activity; increase the activity of catalase (CAT) in the liver, reduce the content of malondialdehyde (MDA), and enhance the immune activity of immunosuppressive model mice.

The team conducts continuous research on polysaccharides and immune functions, and the results have been published in Food Research International (IF 5.

Researcher Zhang Yan

Zhang Yan, researcher, doctoral supervisor of Hebei Medical University School of Forensic Medicine, vice president of Hebei Food Inspection and Research Institute; expert enjoying special allowance from the State Council, first-level candidate of Hebei Province’s "Three Three Three" talent project, top young talent in Hebei Province, Presided over 7 national-level science and technology projects, 23 provincial and ministerial-level projects; scientific research achievements won the special prize of China Business Federation Science and Technology Progress Award, the second prize of Hebei Province Science and Technology Progress Award, the second prize of Henan Province Science and Technology Progress Award and other provincial and ministerial science and technology progress awards Multiple.

Jiang Huimin master student

Jiang Huimin, was admitted to Henan University for a master's degree in Chinese pharmacy in September 2018.

The article "Mechanism of intestinal flora and proteomics in regulating immune function of Durio Zibethinus rind polysaccharide" was published in Oxidative Medicine and Cellular Longevity on February 2, 2021 .